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10.1073/pnas.1411260111 http://scihub22266oqcxt.onion/10.1073/pnas.1411260111 C4460487!4460487!25385609     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (22): 6828-33 Nephropedia Template TP {{tp|p=25385609|t=2015. Stress and the dynamic genome: Steroids, epigenetics, and the transposome |pdf=|usr=}}{{25385609}} gab.com Text Stress and the dynamic genome: Steroids, epigenetics, and the transposome JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25385609 #FOAvip Stress plays a substantial role in shaping behavior and brain function, often with lasting effects. How these lasting effects occur in the context of a fixed postmitotic neuronal genome has been an enduring question for the field. Synaptic plasticity and neurogenesis have provided some of the answers to this question, and more recently epigenetic mechanisms have come to the fore. The exploration of epigenetic mechanisms recently led us to discover that a single acute stress can regulate the expression of retrotransposons in the rat hippocampus via an epigenetic mechanism. We propose that this response may represent a genomic stress response aimed at maintaining genomic and transcriptional stability in vulnerable brain regions such as the hippocampus. This finding and those of other researchers have made clear that retrotransposons and the genomic plasticity they permit play a significant role in brain function during stress and disease. These observations also raise the possibility that the transposome might have adaptive functions at the level of both evolution and the individual organism. Twit Text FOAVip Stress and the dynamic genome: Steroids, epigenetics, and the transposome ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25385609 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25385609 #FOAvip English Wikipedia <ref>{{Cite pmid|25385609}}</ref> Stress and the dynamic genome: Steroids, epigenetics, and the transposome #MMPMID25385609 Hunter RG; Gagnidze K; McEwen BS; Pfaff DW Proc Natl Acad Sci U S A 2015[Jun]; 112 (22): 6828-33 PMID25385609show ga Stress plays a substantial role in shaping behavior and brain function, often with lasting effects. How these lasting effects occur in the context of a fixed postmitotic neuronal genome has been an enduring question for the field. Synaptic plasticity and neurogenesis have provided some of the answers to this question, and more recently epigenetic mechanisms have come to the fore. The exploration of epigenetic mechanisms recently led us to discover that a single acute stress can regulate the expression of retrotransposons in the rat hippocampus via an epigenetic mechanism. We propose that this response may represent a genomic stress response aimed at maintaining genomic and transcriptional stability in vulnerable brain regions such as the hippocampus. This finding and those of other researchers have made clear that retrotransposons and the genomic plasticity they permit play a significant role in brain function during stress and disease. These observations also raise the possibility that the transposome might have adaptive functions at the level of both evolution and the individual organism. äStress and the dynamic genome: Steroids, epigenetics, and the transpos(epmc).pdf DeepDyve Pubget Overpricing