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Microendophenotypes of psychiatric disorders: phenotypes of psychiatric disorders
at the level of molecular dynamics, synapses, neurons, and neural circuits
#MMPMID25732153
Kida S
; Kato T
Curr Mol Med
2015[]; 15
(2
): 111-8
PMID25732153
show ga
Psychiatric disorders are caused not only by genetic factors but also by
complicated factors such as environmental ones. Moreover, environmental factors
are rarely quantitated as biological and biochemical indicators, making it
extremely difficult to understand the pathological conditions of psychiatric
disorders as well as their underlying pathogenic mechanisms. Additionally, we
have actually no other option but to perform biological studies on postmortem
human brains that display features of psychiatric disorders, thereby resulting in
a lack of experimental materials to characterize the basic biology of these
disorders. From these backgrounds, animal, tissue, or cell models that can be
used in basic research are indispensable to understand biologically the
pathogenic mechanisms of psychiatric disorders. In this review, we discuss the
importance of microendophenotypes of psychiatric disorders, i.e., phenotypes at
the level of molecular dynamics, neurons, synapses, and neural circuits, as
targets of basic research on these disorders.
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