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Phospholipid Remodeling and Eicosanoid Signaling in Colon Cancer Cells #MMPMID25823224
Das S; Martinez LR; Ray S
Indian J Biochem Biophys 2014[Dec]; 51 (6): 512-9 PMID25823224show ga
Phospholipid remodeling and eicosanoid synthesis are central to lipid-based inflammatory reactions. Studies have revealed that membrane phospholipid remodeling by fatty acids through deacylation/reacylation reactions increases the risk of colorectal cancers (CRC) by allowing the cells to produce excess inflammatory eicosanoids such as prostaglandins, thromboxanes, and leukotrienes. Over the years, efforts have been made to understand the lipid remodeling pathways and to design anti-cancer drugs targeting the enzymes of eicosanoid biosynthesis. Here, we discuss the recent progress in phospholipid remodeling and eicosanoid biosynthesis in CRC.