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10.1111/jcmm.12527 http://scihub22266oqcxt.onion/10.1111/jcmm.12527 C4459853!4459853 !25781495     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25781495 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Cell+Mol+Med 2015 ; 19 (6 ): 1400-9 Nephropedia Template TP {{tp|p=25781495 |t=2015. Renalase contributes to the renal protection of delayed ischaemic preconditioning via the regulation of hypoxia-inducible factor-1? |pdf=|usr=}}{{25781495 }} gab.com Text Renalase contributes to the renal protection of delayed ischaemic preconditioning via the regulation of hypoxia-inducible factor-1 JO: J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=25781495 #FOAvip Ischaemic preconditioning (IPC) attenuates acute kidney injury (AKI) from renal ischaemia reperfusion. Renalase, an amine oxidase secreted by the proximal tubule, not only degrades circulating catecholamines but also protects against renal ischaemia reperfusion injury. Here, it has been suggested that the renoprotective effect of renal IPC is partly mediated by renalase. In a model of brief intermittent renal IPC, the increased cortex renalase expression was found to last for 48 hrs. IPC significantly reduced renal tubular inflammation, necrosis and oxidative stress following renal ischaemia reperfusion injury. Such effects were attenuated by blocking renalase with an anti-renalase monoclonal antibody. We further demonstrated that renalase expression was up-regulated by hypoxia in vitro via an hypoxia-inducible factor (HIF)-1? mechanism. The IPC-induced up-regulation of renalase in vivo was also reduced by pre-treatment with an HIF-1? inhibitor, 3-(5'-Hydroxymethyl-2'-furyl)-1-benzyl indazole. In summary, the renoprotective effect of IPC is partly dependent on the renalase expression, which may be triggered by hypoxia via an HIF-1? mechanism. Endogenous renalase shows potential as a therapeutic agent for the prevention and treatment of AKI. Twit Text FOAVip Renalase contributes to the renal protection of delayed ischaemic preconditioning via the regulation of hypoxia-inducible factor-1 ????J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=25781495 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25781495 #FOAvip English Wikipedia <ref>{{Cite pmid|25781495 }}</ref> Renalase contributes to the renal protection of delayed ischaemic preconditioning via the regulation of hypoxia-inducible factor-1? #MMPMID25781495 Wang F ; Zhang G ; Xing T ; Lu Z ; Li J ; Peng C ; Liu G ; Wang N J Cell Mol Med 2015[Jun]; 19 (6 ): 1400-9 PMID25781495 show ga Ischaemic preconditioning (IPC) attenuates acute kidney injury (AKI) from renal ischaemia reperfusion. Renalase, an amine oxidase secreted by the proximal tubule, not only degrades circulating catecholamines but also protects against renal ischaemia reperfusion injury. Here, it has been suggested that the renoprotective effect of renal IPC is partly mediated by renalase. In a model of brief intermittent renal IPC, the increased cortex renalase expression was found to last for 48 hrs. IPC significantly reduced renal tubular inflammation, necrosis and oxidative stress following renal ischaemia reperfusion injury. Such effects were attenuated by blocking renalase with an anti-renalase monoclonal antibody. We further demonstrated that renalase expression was up-regulated by hypoxia in vitro via an hypoxia-inducible factor (HIF)-1? mechanism. The IPC-induced up-regulation of renalase in vivo was also reduced by pre-treatment with an HIF-1? inhibitor, 3-(5'-Hydroxymethyl-2'-furyl)-1-benzyl indazole. In summary, the renoprotective effect of IPC is partly dependent on the renalase expression, which may be triggered by hypoxia via an HIF-1? mechanism. Endogenous renalase shows potential as a therapeutic agent for the prevention and treatment of AKI. |*Ischemic Preconditioning [MESH] |Animals [MESH] |Blotting, Western [MESH] |Cell Hypoxia [MESH] |Cell Line [MESH] |Gene Expression Regulation, Enzymologic [MESH] |Humans [MESH] |Hypoxia [MESH] |Hypoxia-Inducible Factor 1, alpha Subunit/*metabolism [MESH] |Kidney/blood supply/enzymology/*metabolism [MESH] |Male [MESH] |Monoamine Oxidase/genetics/*metabolism [MESH] |Protective Agents/metabolism [MESH] |Rats, Sprague-Dawley [MESH] |Reperfusion Injury/genetics/metabolism/prevention & control [MESH] |Reverse Transcriptase Polymerase Chain Reaction [MESH]Renalase contributes to the renal protection of delayed ischaemic prec(epmc).pdf DeepDyve Pubget Overpricing