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10.1111/jcmm.12467 http://scihub22266oqcxt.onion/10.1111/jcmm.12467 C4459838!4459838 !25810125     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25810125 &cmd=llinks): Failed to open stream: HTTP request failed! 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PD-1/PD-L1 expression on CD(4+) T cells and myeloid DCs correlates with the immune pathogenesis of atrial fibrillation |pdf=|usr=}}{{25810125 }} gab.com Text PD-1/PD-L1 expression on CD(4+) T cells and myeloid DCs correlates with the immune pathogenesis of atrial fibrillation JO: J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=25810125 #FOAvip Although immuno-inflammatory response contributes to pathogenesis of AF, molecular and cellular mechanism in this process remains poorly understood. Recently, increasing evidence suggests that Programmed death-1 (PD-1)/PD-1 ligand (PD-L) pathway may be a potential pathway participating in AF pathogenesis. In this study, we detected the PD-1 and PD-L1, 2 expression on peripheral blood function cells by flow cytometry in 91 atrial fibrillation (AF) patients and 35 healthy volunteers. The expression of PD-1 on CD(4+) T cells and PD-L1 on myeloid dendritic cells (mDCs) in AF patients is significantly down-regulated compared with healthy volunteers. In addition, the extent of PD-1/PD-L1 down-regulation is closely related with AF burden. More importantly, Allogeneic mixed leukocyte reactions (MLR) shows that the mDCs PD-L1 down-regulation is associated with increased T cell (CD(4+) and CD(8+)) proliferation, increased type 1 effector cytokines (IL-2 and IFN-?) secretion, and decreased type 2 effector cytokine (IL-10) secretion. Then, PD-L1 up-regulation by the stimulation of IFN-? can significantly convert this representation. Collectively, our report suggest that T(CD(4+))/mDCs-associated PD-1/PD-L1 pathway plays a key role in AF immune regulation. PD-1/PD-L1 down-regulation in AF patients promotes T cells function and may contribute to AF pathogenesis. Twit Text FOAVip PD-1/PD-L1 expression on CD(4+) T cells and myeloid DCs correlates with the immune pathogenesis of atrial fibrillation ????J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=25810125 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25810125 #FOAvip English Wikipedia <ref>{{Cite pmid|25810125 }}</ref> PD-1/PD-L1 expression on CD(4+) T cells and myeloid DCs correlates with the immune pathogenesis of atrial fibrillation #MMPMID25810125 Liu L ; Zheng Q ; Lee J ; Ma Z ; Zhu Q ; Wang Z J Cell Mol Med 2015[Jun]; 19 (6 ): 1223-33 PMID25810125 show ga Although immuno-inflammatory response contributes to pathogenesis of AF, molecular and cellular mechanism in this process remains poorly understood. Recently, increasing evidence suggests that Programmed death-1 (PD-1)/PD-1 ligand (PD-L) pathway may be a potential pathway participating in AF pathogenesis. In this study, we detected the PD-1 and PD-L1, 2 expression on peripheral blood function cells by flow cytometry in 91 atrial fibrillation (AF) patients and 35 healthy volunteers. The expression of PD-1 on CD(4+) T cells and PD-L1 on myeloid dendritic cells (mDCs) in AF patients is significantly down-regulated compared with healthy volunteers. In addition, the extent of PD-1/PD-L1 down-regulation is closely related with AF burden. More importantly, Allogeneic mixed leukocyte reactions (MLR) shows that the mDCs PD-L1 down-regulation is associated with increased T cell (CD(4+) and CD(8+)) proliferation, increased type 1 effector cytokines (IL-2 and IFN-?) secretion, and decreased type 2 effector cytokine (IL-10) secretion. Then, PD-L1 up-regulation by the stimulation of IFN-? can significantly convert this representation. Collectively, our report suggest that T(CD(4+))/mDCs-associated PD-1/PD-L1 pathway plays a key role in AF immune regulation. PD-1/PD-L1 down-regulation in AF patients promotes T cells function and may contribute to AF pathogenesis. |Aged [MESH] |Atrial Fibrillation/*immunology/metabolism [MESH] |B7-H1 Antigen/*immunology/metabolism [MESH] |CD4-Positive T-Lymphocytes/*immunology/metabolism [MESH] |CD8-Positive T-Lymphocytes/immunology/metabolism [MESH] |Cell Proliferation [MESH] |Cells, Cultured [MESH] |Dendritic Cells/*immunology/metabolism [MESH] |Down-Regulation/immunology [MESH] |Female [MESH] |Flow Cytometry [MESH] |Humans [MESH] |Interferon-gamma/immunology/metabolism [MESH] |Interleukin-10/immunology/metabolism [MESH] |Interleukin-2/immunology/metabolism [MESH] |Lymphocyte Culture Test, Mixed [MESH] |Male [MESH] |Middle Aged [MESH] |Myeloid Cells/*immunology/metabolism [MESH]PD-1/PD-L1 expression on CD(4+) T cells and myeloid DCs correlates wit(epmc).pdf DeepDyve Pubget Overpricing