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10.15252/emmm.201404511 http://scihub22266oqcxt.onion/10.15252/emmm.201404511 C4459813!4459813!25825391     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25825391&cmd=llinks): Failed to open stream: HTTP request failed! 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Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron?sulfur deficiency and pulmonary hypertension |pdf=|usr=}}{{25825391}} gab.com Text Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron sulfur deficiency and pulmonary hypertension JO: EMBO Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=25825391 #FOAvip Iron?sulfur (Fe-S) clusters are essential for mitochondrial metabolism, but their regulation in pulmonary hypertension (PH) remains enigmatic. We demonstrate that alterations of the miR-210-ISCU1/2 axis cause Fe-S deficiencies in vivo and promote PH. In pulmonary vascular cells and particularly endothelium, hypoxic induction of miR-210 and repression of the miR-210 targets ISCU1/2 down-regulated Fe-S levels. In mouse and human vascular and endothelial tissue affected by PH, miR-210 was elevated accompanied by decreased ISCU1/2 and Fe-S integrity. In mice, miR-210 repressed ISCU1/2 and promoted PH. Mice deficient in miR-210, via genetic/pharmacologic means or via an endothelial-specific manner, displayed increased ISCU1/2 and were resistant to Fe-S-dependent pathophenotypes and PH. Similar to hypoxia or miR-210 overexpression, ISCU1/2 knockdown also promoted PH. Finally, cardiopulmonary exercise testing of a woman with homozygous ISCU mutations revealed exercise-induced pulmonary vascular dysfunction. Thus, driven by acquired (hypoxia) or genetic causes, the miR-210-ISCU1/2 regulatory axis is a pathogenic lynchpin causing Fe-S deficiency and PH. These findings carry broad translational implications for defining the metabolic origins of PH and potentially other metabolic diseases sharing similar underpinnings. Twit Text FOAVip Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron sulfur deficiency and pulmonary hypertension ????EMBO Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=25825391 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25825391 #FOAvip English Wikipedia <ref>{{Cite pmid|25825391}}</ref> Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron?sulfur deficiency and pulmonary hypertension #MMPMID25825391 White K; Lu Y; Annis S; Hale AE; Chau BN; Dahlman JE; Hemann C; Opotowsky AR; Vargas SO; Rosas I; Perrella MA; Osorio JC; Haley KJ; Graham BB; Kumar R; Saggar R; Saggar R; Wallace WD; Ross DJ; Khan OF; Bader A; Gochuico BR; Matar M; Polach K; Johannessen NM; Prosser HM; Anderson DG; Langer R; Zweier JL; Bindoff LA; Systrom D; Waxman AB; Jin RC; Chan SY EMBO Mol Med 2015[Jun]; 7 (6): 695-713 PMID25825391show ga Iron?sulfur (Fe-S) clusters are essential for mitochondrial metabolism, but their regulation in pulmonary hypertension (PH) remains enigmatic. We demonstrate that alterations of the miR-210-ISCU1/2 axis cause Fe-S deficiencies in vivo and promote PH. In pulmonary vascular cells and particularly endothelium, hypoxic induction of miR-210 and repression of the miR-210 targets ISCU1/2 down-regulated Fe-S levels. In mouse and human vascular and endothelial tissue affected by PH, miR-210 was elevated accompanied by decreased ISCU1/2 and Fe-S integrity. In mice, miR-210 repressed ISCU1/2 and promoted PH. Mice deficient in miR-210, via genetic/pharmacologic means or via an endothelial-specific manner, displayed increased ISCU1/2 and were resistant to Fe-S-dependent pathophenotypes and PH. Similar to hypoxia or miR-210 overexpression, ISCU1/2 knockdown also promoted PH. Finally, cardiopulmonary exercise testing of a woman with homozygous ISCU mutations revealed exercise-induced pulmonary vascular dysfunction. Thus, driven by acquired (hypoxia) or genetic causes, the miR-210-ISCU1/2 regulatory axis is a pathogenic lynchpin causing Fe-S deficiency and PH. These findings carry broad translational implications for defining the metabolic origins of PH and potentially other metabolic diseases sharing similar underpinnings. äGenetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promo(epmc).pdf DeepDyve Pubget Overpricing