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10.15252/emmm.201505161

http://scihub22266oqcxt.onion/10.15252/emmm.201505161
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suck abstract from ncbi


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pmid25859016
      EMBO+Mol+Med 2015 ; 7 (6 ): 692-4
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  • A new twist to the emerging functions of ceramides in cancer: novel role for platelet acid sphingomyelinase in cancer metastasis #MMPMID25859016
  • Hannun YA ; Newcomb B
  • EMBO Mol Med 2015[Jun]; 7 (6 ): 692-4 PMID25859016 show ga
  • It is now appreciated that sphingolipids constitute a rich class of bioactive molecules that include ceramide, sphingosine, and sphingosine 1?phosphate whose formation is controlled by a network of highly regulated enzymes (Hannun & Obeid, 2008). Notably, several stress stimuli induce the production of ceramide, which, as a single entity, has been traditionally associated with apoptotic and growth suppressive functions. However, recent data clearly suggest that this simplistic formulation is no longer tenable.
  • |Animals [MESH]
  • |Melanoma/*secondary [MESH]
  • |Neoplasm Metastasis/*physiopathology [MESH]


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