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2015 ; 7
(6
): 692-4
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
A new twist to the emerging functions of ceramides in cancer: novel role for
platelet acid sphingomyelinase in cancer metastasis
#MMPMID25859016
Hannun YA
; Newcomb B
EMBO Mol Med
2015[Jun]; 7
(6
): 692-4
PMID25859016
show ga
It is now appreciated that sphingolipids constitute a rich class of bioactive
molecules that include ceramide, sphingosine, and sphingosine 1?phosphate whose
formation is controlled by a network of highly regulated enzymes (Hannun & Obeid,
2008). Notably, several stress stimuli induce the production of ceramide, which,
as a single entity, has been traditionally associated with apoptotic and growth
suppressive functions. However, recent data clearly suggest that this simplistic
formulation is no longer tenable.