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10.1016/j.jaut.2015.01.003 http://scihub22266oqcxt.onion/10.1016/j.jaut.2015.01.003 C4459745!4459745!25841937     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Autoimmun 2015 ; 59 (ä): 8-18 Nephropedia Template TP {{tp|p=25841937|t=2015. Autoimmunity to the alpha 3 chain of type IV collagen in glomerulonephritis is triggered by ?autoantigen complementarity? |pdf=|usr=}}{{25841937}} gab.com Text Autoimmunity to the alpha 3 chain of type IV collagen in glomerulonephritis is triggered by autoantigen complementarity JO: J Autoimmun http://www.kidney.de/pget.php?&tw=1&pmid=25841937 #FOAvip ?Autoantigen complementarity? is a theory proposing that the initiator of an autoimmune response is not necessarily the autoantigen or its molecular mimic, but may instead be a peptide that is ?antisense/complementary? to the autoantigen. We investigated whether such complementary proteins play a role in the immunopathogenesis of autoimmune glomerulonephritis. Experimental autoimmune glomerulonephritis, a model of anti-glomerular basement membrane (GBM) disease, can be induced in Wistar Kyoto (WKY) rats by immunization with the ?3 chain of type IV collagen. In this study, WKY rats were immunized with a complementary ?3 peptide (c-?3-Gly) comprised of amino acids that ?complement? the well characterized epitope on ?3(IV)NC1, pCol(24?38). Within 8 weeks post-immunization, these animals developed cresentic glomerulonephritis, similar to pCol(24?38)-immunized rats, while animals immunized with scrambled peptide were normal. Anti-idiotypic antibodies to epitopes from c-?3-Gly-immunized animals were shown to be specific for ?3 protein, binding in a region containing sense pCol(24?38) sequence. Interestingly, anticomplementary ?3 antibodies were identified in sera from patients with anti-GBM disease, suggesting a role for ?autoantigen complementarity? in immunopathogenesis of the human disease. This work supports the idea that autoimmune glomerulonephritis can be initiated through an immune response against a peptide that is anti-sense or complementary to the autoantigen. The implications of this discovery may be far reaching, and other autoimmune diseases could be due to responses to these once unsuspected ?complementary? antigens. Twit Text FOAVip Autoimmunity to the alpha 3 chain of type IV collagen in glomerulonephritis is triggered by autoantigen complementarity ????J Autoimmun http://www.kidney.de/pget.php?&tw=1&pmid=25841937 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25841937 #FOAvip English Wikipedia <ref>{{Cite pmid|25841937}}</ref> Autoimmunity to the alpha 3 chain of type IV collagen in glomerulonephritis is triggered by ?autoantigen complementarity? #MMPMID25841937 Reynolds J; Preston GA; Pressler BM; Hewins P; Brown M; Roth A; Alderman E; Bunch D; Jennette JC; Cook HT; Falk RJ; Pusey CD J Autoimmun 2015[May]; 59 (ä): 8-18 PMID25841937show ga ?Autoantigen complementarity? is a theory proposing that the initiator of an autoimmune response is not necessarily the autoantigen or its molecular mimic, but may instead be a peptide that is ?antisense/complementary? to the autoantigen. We investigated whether such complementary proteins play a role in the immunopathogenesis of autoimmune glomerulonephritis. Experimental autoimmune glomerulonephritis, a model of anti-glomerular basement membrane (GBM) disease, can be induced in Wistar Kyoto (WKY) rats by immunization with the ?3 chain of type IV collagen. In this study, WKY rats were immunized with a complementary ?3 peptide (c-?3-Gly) comprised of amino acids that ?complement? the well characterized epitope on ?3(IV)NC1, pCol(24?38). Within 8 weeks post-immunization, these animals developed cresentic glomerulonephritis, similar to pCol(24?38)-immunized rats, while animals immunized with scrambled peptide were normal. Anti-idiotypic antibodies to epitopes from c-?3-Gly-immunized animals were shown to be specific for ?3 protein, binding in a region containing sense pCol(24?38) sequence. Interestingly, anticomplementary ?3 antibodies were identified in sera from patients with anti-GBM disease, suggesting a role for ?autoantigen complementarity? in immunopathogenesis of the human disease. This work supports the idea that autoimmune glomerulonephritis can be initiated through an immune response against a peptide that is anti-sense or complementary to the autoantigen. The implications of this discovery may be far reaching, and other autoimmune diseases could be due to responses to these once unsuspected ?complementary? antigens. äAutoimmunity to the alpha 3 chain of type IV collagen in glomeruloneph(epmc).pdf DeepDyve Pubget Overpricing