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10.1016/j.cell.2015.04.053 http://scihub22266oqcxt.onion/10.1016/j.cell.2015.04.053 C4459712!4459712!26046444     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2015 ; 161 (6): 1453-67 Nephropedia Template TP {{tp|p=26046444|t=2015. A Unique Gene Regulatory Network Resets the Human Germline Epigenome for Development |pdf=|usr=}}{{26046444}} gab.com Text A Unique Gene Regulatory Network Resets the Human Germline Epigenome for Development JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=26046444 #FOAvip Resetting of the epigenome in human primordial germ cells (hPGCs) is critical for development. We show that the transcriptional program of hPGCs is distinct from that in mice, with co-expression of somatic specifiers and naive pluripotency genes TFCP2L1 and KLF4. This unique gene regulatory network, established by SOX17 and BLIMP1, drives comprehensive germline DNA demethylation by repressing DNA methylation pathways and activating TET-mediated hydroxymethylation. Base-resolution methylome analysis reveals progressive DNA demethylation to basal levels in week 5?7 in vivo hPGCs. Concurrently, hPGCs undergo chromatin reorganization, X reactivation, and imprint erasure. Despite global hypomethylation, evolutionarily young and potentially hazardous retroelements, like SVA, remain methylated. Remarkably, some loci associated with metabolic and neurological disorders are also resistant to DNA demethylation, revealing potential for transgenerational epigenetic inheritance that may have phenotypic consequences. We provide comprehensive insight on early human germline transcriptional network and epigenetic reprogramming that subsequently impacts human development and disease. Twit Text FOAVip A Unique Gene Regulatory Network Resets the Human Germline Epigenome for Development ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=26046444 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26046444 #FOAvip English Wikipedia <ref>{{Cite pmid|26046444}}</ref> A Unique Gene Regulatory Network Resets the Human Germline Epigenome for Development #MMPMID26046444 Tang W; Dietmann S; Irie N; Leitch H; Floros V; Bradshaw C; Hackett J; Chinnery P; Surani M Cell 2015[Jun]; 161 (6): 1453-67 PMID26046444show ga Resetting of the epigenome in human primordial germ cells (hPGCs) is critical for development. We show that the transcriptional program of hPGCs is distinct from that in mice, with co-expression of somatic specifiers and naive pluripotency genes TFCP2L1 and KLF4. This unique gene regulatory network, established by SOX17 and BLIMP1, drives comprehensive germline DNA demethylation by repressing DNA methylation pathways and activating TET-mediated hydroxymethylation. Base-resolution methylome analysis reveals progressive DNA demethylation to basal levels in week 5?7 in vivo hPGCs. Concurrently, hPGCs undergo chromatin reorganization, X reactivation, and imprint erasure. Despite global hypomethylation, evolutionarily young and potentially hazardous retroelements, like SVA, remain methylated. Remarkably, some loci associated with metabolic and neurological disorders are also resistant to DNA demethylation, revealing potential for transgenerational epigenetic inheritance that may have phenotypic consequences. We provide comprehensive insight on early human germline transcriptional network and epigenetic reprogramming that subsequently impacts human development and disease. äA Unique Gene Regulatory Network Resets the Human Germline Epigenome f(epmc).pdf DeepDyve Pubget Overpricing