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10.1038/srep11067 http://scihub22266oqcxt.onion/10.1038/srep11067 C4459200!4459200!26053434     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2015 ; 5 (ä): ä Nephropedia Template TP {{tp|p=26053434|t=2015. Biorealistic cardiac cell culture platforms with integrated monitoring of extracellular action potentials |pdf=|usr=}}{{26053434}} gab.com Text Biorealistic cardiac cell culture platforms with integrated monitoring of extracellular action potentials JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26053434 #FOAvip Current platforms for in vitro drug development utilize confluent, unorganized monolayers of heart cells to study the effect on action potential propagation. However, standard cell cultures are of limited use in cardiac research, as they do not preserve important structural and functional properties of the myocardium. Here we present a method to integrate a scaffolding technology with multi-electrode arrays and deliver a compact, off-the-shelf monitoring platform for growing biomimetic cardiac tissue. Our approach produces anisotropic cultures with conduction velocity (CV) profiles that closer resemble native heart tissue; the fastest impulse propagation is along the long axis of the aligned cardiomyocytes (CVL) and the slowest propagation is perpendicular (CVT), in contrast to standard cultures where action potential propagates isotropically (CVL???CVT). The corresponding anisotropy velocity ratios (CVL/CVT?=?1.38???2.22) are comparable with values for healthy adult rat ventricles (1.98???3.63). The main advantages of this approach are that (i) it provides ultimate pattern control, (ii) it is compatible with automated manufacturing steps and (iii) it is utilized through standard cell culturing protocols. Our platform is compatible with existing read-out equipment and comprises a prompt method for more reliable CV studies. Twit Text FOAVip Biorealistic cardiac cell culture platforms with integrated monitoring of extracellular action potentials ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26053434 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26053434 #FOAvip English Wikipedia <ref>{{Cite pmid|26053434}}</ref> Biorealistic cardiac cell culture platforms with integrated monitoring of extracellular action potentials #MMPMID26053434 Trantidou T; Terracciano CM; Kontziampasis D; Humphrey EJ; Prodromakis T Sci Rep 2015[]; 5 (ä): ä PMID26053434show ga Current platforms for in vitro drug development utilize confluent, unorganized monolayers of heart cells to study the effect on action potential propagation. However, standard cell cultures are of limited use in cardiac research, as they do not preserve important structural and functional properties of the myocardium. Here we present a method to integrate a scaffolding technology with multi-electrode arrays and deliver a compact, off-the-shelf monitoring platform for growing biomimetic cardiac tissue. Our approach produces anisotropic cultures with conduction velocity (CV) profiles that closer resemble native heart tissue; the fastest impulse propagation is along the long axis of the aligned cardiomyocytes (CVL) and the slowest propagation is perpendicular (CVT), in contrast to standard cultures where action potential propagates isotropically (CVL???CVT). The corresponding anisotropy velocity ratios (CVL/CVT?=?1.38???2.22) are comparable with values for healthy adult rat ventricles (1.98???3.63). The main advantages of this approach are that (i) it provides ultimate pattern control, (ii) it is compatible with automated manufacturing steps and (iii) it is utilized through standard cell culturing protocols. Our platform is compatible with existing read-out equipment and comprises a prompt method for more reliable CV studies. äBiorealistic cardiac cell culture platforms with integrated monitoring(epmc).pdf DeepDyve Pubget Overpricing