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10.1038/srep11084

http://scihub22266oqcxt.onion/10.1038/srep11084
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C4459174!4459174 !26053666
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suck abstract from ncbi


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pmid26053666
      Sci+Rep 2015 ; 5 (ä): 11084
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  • The Clinical Features and Bacteriological Characterizations of Bone and Joint Tuberculosis in China #MMPMID26053666
  • Chen ST ; Zhao LP ; Dong WJ ; Gu YT ; Li YX ; Dong LL ; Ma YF ; Qin SB ; Huang HR
  • Sci Rep 2015[Jun]; 5 (ä): 11084 PMID26053666 show ga
  • Bone and Joint tuberculosis (BJTB) constitutes about 10% of total extra-pulmonary TB cases. Since the BJTB is a paucibacillary condition, there has been no systematic study on the bacterial characterization, especially the epidemiological feature. Here we collected the mycobacterial clinical isolates, analyzed the clinical features and the bacteriological characteristics from 113 BJTB cases reported in China. The mean age of the cases was 40.33 years while most of the patients fell into the 20-29 year age group; local pain was the most common onset symptom of BJTB cases; mean time from symptom onset to BJTB diagnosis was 13.16 months. 31 isolates were defined as drug resistant, including 15 multidrug resistant (MDR) and 2 extensively drug resistant (XDR) isolates according to the drug susceptibility test outcomes; after spoligotyping, 87.6% (99/113) isolates were categorized as Beijing family. In contrast to the isolates from pulmonary tuberculosis patients, here the MIRU-VNTR assay did not find anything significant. A prolonged time span for BJTB diagnosis highlights the requirement of paying further attention to BJTB infection in China. This study provides essential insights into the demographic and microbial characteristics of BJTB cases in China.
  • |Adolescent [MESH]
  • |Adult [MESH]
  • |Aged [MESH]
  • |Aged, 80 and over [MESH]
  • |Antitubercular Agents/therapeutic use [MESH]
  • |Bone and Bones/*microbiology/pathology [MESH]
  • |Child [MESH]
  • |China [MESH]
  • |DNA, Intergenic/genetics [MESH]
  • |Drug Resistance, Multiple, Bacterial/genetics [MESH]
  • |Female [MESH]
  • |Humans [MESH]
  • |Joints/*microbiology/pathology [MESH]
  • |Male [MESH]
  • |Microbial Sensitivity Tests [MESH]
  • |Middle Aged [MESH]
  • |Molecular Typing [MESH]
  • |Mycobacterium tuberculosis/drug effects/genetics/*isolation & purification [MESH]
  • |RNA, Ribosomal, 16S/genetics [MESH]
  • |RNA, Ribosomal, 23S/genetics [MESH]
  • |Retrospective Studies [MESH]
  • |Tuberculosis, Osteoarticular/drug therapy/*microbiology/pathology [MESH]
  • |Tuberculosis, Pulmonary/genetics/*microbiology/pathology [MESH]


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