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2015 ; 5
(ä): 11084
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The Clinical Features and Bacteriological Characterizations of Bone and Joint
Tuberculosis in China
#MMPMID26053666
Chen ST
; Zhao LP
; Dong WJ
; Gu YT
; Li YX
; Dong LL
; Ma YF
; Qin SB
; Huang HR
Sci Rep
2015[Jun]; 5
(ä): 11084
PMID26053666
show ga
Bone and Joint tuberculosis (BJTB) constitutes about 10% of total extra-pulmonary
TB cases. Since the BJTB is a paucibacillary condition, there has been no
systematic study on the bacterial characterization, especially the
epidemiological feature. Here we collected the mycobacterial clinical isolates,
analyzed the clinical features and the bacteriological characteristics from 113
BJTB cases reported in China. The mean age of the cases was 40.33 years while
most of the patients fell into the 20-29 year age group; local pain was the most
common onset symptom of BJTB cases; mean time from symptom onset to BJTB
diagnosis was 13.16 months. 31 isolates were defined as drug resistant, including
15 multidrug resistant (MDR) and 2 extensively drug resistant (XDR) isolates
according to the drug susceptibility test outcomes; after spoligotyping, 87.6%
(99/113) isolates were categorized as Beijing family. In contrast to the isolates
from pulmonary tuberculosis patients, here the MIRU-VNTR assay did not find
anything significant. A prolonged time span for BJTB diagnosis highlights the
requirement of paying further attention to BJTB infection in China. This study
provides essential insights into the demographic and microbial characteristics of
BJTB cases in China.