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10.3389/fimmu.2015.00272 http://scihub22266oqcxt.onion/10.3389/fimmu.2015.00272 C4459100!4459100!26106387     free     free     free       Front+Immunol 2015 ; 6 (ä): ä Nephropedia Template TP {{tp|p=26106387|t=2015. Pathogenesis of Systemic Sclerosis |pdf=|usr=}}{{26106387}} gab.com Text Pathogenesis of Systemic Sclerosis JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26106387 #FOAvip Systemic scleroderma (SSc) is one of the most complex systemic autoimmune diseases. It targets the vasculature, connective tissue-producing cells (namely fibroblasts/myofibroblasts), and components of the innate and adaptive immune systems. Clinical and pathologic manifestations of SSc are the result of: (1) innate/adaptive immune system abnormalities leading to production of autoantibodies and cell-mediated autoimmunity, (2) microvascular endothelial cell/small vessel fibroproliferative vasculopathy, and (3) fibroblast dysfunction generating excessive accumulation of collagen and other matrix components in skin and internal organs. All three of these processes interact and affect each other. The disease is heterogeneous in its clinical presentation that likely reflects different genetic or triggering factor (i.e., infection or environmental toxin) influences on the immune system, vasculature, and connective tissue cells. The roles played by other ubiquitous molecular entities (such as lysophospholipids, endocannabinoids, and their diverse receptors and vitamin D) in influencing the immune system, vasculature, and connective tissue cells are just beginning to be realized and studied and may provide insights into new therapeutic approaches to treat SSc. Twit Text FOAVip Pathogenesis of Systemic Sclerosis ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26106387 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26106387 #FOAvip English Wikipedia <ref>{{Cite pmid|26106387}}</ref> Pathogenesis of Systemic Sclerosis #MMPMID26106387 Pattanaik D; Brown M; Postlethwaite BC; Postlethwaite AE Front Immunol 2015[]; 6 (ä): ä PMID26106387show ga Systemic scleroderma (SSc) is one of the most complex systemic autoimmune diseases. It targets the vasculature, connective tissue-producing cells (namely fibroblasts/myofibroblasts), and components of the innate and adaptive immune systems. Clinical and pathologic manifestations of SSc are the result of: (1) innate/adaptive immune system abnormalities leading to production of autoantibodies and cell-mediated autoimmunity, (2) microvascular endothelial cell/small vessel fibroproliferative vasculopathy, and (3) fibroblast dysfunction generating excessive accumulation of collagen and other matrix components in skin and internal organs. All three of these processes interact and affect each other. The disease is heterogeneous in its clinical presentation that likely reflects different genetic or triggering factor (i.e., infection or environmental toxin) influences on the immune system, vasculature, and connective tissue cells. The roles played by other ubiquitous molecular entities (such as lysophospholipids, endocannabinoids, and their diverse receptors and vitamin D) in influencing the immune system, vasculature, and connective tissue cells are just beginning to be realized and studied and may provide insights into new therapeutic approaches to treat SSc. äPathogenesis of Systemic Sclerosis (epmc).pdf DeepDyve Pubget Overpricing