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10.3389/fbioe.2015.00081

http://scihub22266oqcxt.onion/10.3389/fbioe.2015.00081
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C4459096!4459096!26106596
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suck abstract from ncbi


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pmid26106596      Front+Bioeng+Biotechnol 2015 ; 3 (ä): ä
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  • 3D Printing of Octacalcium Phosphate Bone Substitutes #MMPMID26106596
  • Komlev VS; Popov VK; Mironov AV; Fedotov AY; Teterina AY; Smirnov IV; Bozo IY; Rybko VA; Deev RV
  • Front Bioeng Biotechnol 2015[]; 3 (ä): ä PMID26106596show ga
  • Biocompatible calcium phosphate ceramic grafts are able of supporting new bone formation in appropriate environment. The major limitation of these materials usage for medical implants is the absence of accessible methods for their patient-specific fabrication. 3D printing methodology is an excellent approach to overcome the limitation supporting effective and fast fabrication of individual complex bone substitutes. Here, we proposed a relatively simple route for 3D printing of octacalcium phosphates (OCP) in complexly shaped structures by the combination of inkjet printing with post-treatment methodology. The printed OCP blocks were further implanted in the developed cranial bone defect followed by histological evaluation. The obtained result confirmed the potential of the developed OCP bone substitutes, which allowed 2.5-time reducing of defect?s diameter at 6.5?months in a region where native bone repair is extremely inefficient.
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