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10.1038/srep11034 http://scihub22266oqcxt.onion/10.1038/srep11034 C4458912!4458912 !26052106     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26052106 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2015 ; 5 (ä): 11034 Nephropedia Template TP {{tp|p=26052106 |t=2015. Ultra-sensitive protein detection via Single Molecule Arrays towards early stage cancer monitoring |pdf=|usr=}}{{26052106 }} gab.com Text Ultra-sensitive protein detection via Single Molecule Arrays towards early stage cancer monitoring JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26052106 #FOAvip The early diagnosis of cancers and continued monitoring of tumor growth would be greatly facilitated by the development of a blood-based, non-invasive, screening technique for early cancer detection. Current technologies for cancer screening and detection typically rely on imaging techniques or blood tests that are not accurate or sensitive enough to definitively diagnose cancer at its earliest stages or predict biologic outcomes. By utilizing Single Molecule Arrays (SiMoA), an ultra-sensitive enzyme-linked immunosorbent assay (ELISA) technique, we were able to measure increasing levels of prostate specific antigen (PSA) within murine serum over time, which we attribute to tumor development. The measured concentrations of PSA were well below the detectable limits of both a leading clinical diagnostic PSA ELISA assay as well as a commercial ultra-sensitive PSA assay. Our work benchmarks the role of SiMoA as a vital tool in monitoring previously non-detectable protein biomarkers in serum for early cancer detection and offers significant potential as a non-invasive platform for the monitoring of early stage cancer. Twit Text FOAVip Ultra-sensitive protein detection via Single Molecule Arrays towards early stage cancer monitoring ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26052106 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26052106 #FOAvip English Wikipedia <ref>{{Cite pmid|26052106 }}</ref> Ultra-sensitive protein detection via Single Molecule Arrays towards early stage cancer monitoring #MMPMID26052106 Schubert SM ; Arendt LM ; Zhou W ; Baig S ; Walter SR ; Buchsbaum RJ ; Kuperwasser C ; Walt DR Sci Rep 2015[Jun]; 5 (ä): 11034 PMID26052106 show ga The early diagnosis of cancers and continued monitoring of tumor growth would be greatly facilitated by the development of a blood-based, non-invasive, screening technique for early cancer detection. Current technologies for cancer screening and detection typically rely on imaging techniques or blood tests that are not accurate or sensitive enough to definitively diagnose cancer at its earliest stages or predict biologic outcomes. By utilizing Single Molecule Arrays (SiMoA), an ultra-sensitive enzyme-linked immunosorbent assay (ELISA) technique, we were able to measure increasing levels of prostate specific antigen (PSA) within murine serum over time, which we attribute to tumor development. The measured concentrations of PSA were well below the detectable limits of both a leading clinical diagnostic PSA ELISA assay as well as a commercial ultra-sensitive PSA assay. Our work benchmarks the role of SiMoA as a vital tool in monitoring previously non-detectable protein biomarkers in serum for early cancer detection and offers significant potential as a non-invasive platform for the monitoring of early stage cancer. |Animals [MESH] |Cell Line, Tumor [MESH] |Enzyme-Linked Immunosorbent Assay/methods [MESH] |Humans [MESH] |Kallikreins/*blood [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred NOD [MESH] |Mice, SCID [MESH] |Monitoring, Physiologic/*methods [MESH] |Neoplasm Staging [MESH] |Neoplasms, Experimental/*blood [MESH] |Prostate-Specific Antigen/*blood [MESH] |Prostatic Neoplasms/*blood [MESH] |Protein Array Analysis/*methods [MESH]Ultra-sensitive protein detection via Single Molecule Arrays towards e(epmc).pdf DeepDyve Pubget Overpricing