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2015 ; 69
(6
): 707-11
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Vitamin D supplementation in obese type 2 diabetes subjects in Ajman, UAE: a
randomized controlled double-blinded clinical trial
#MMPMID25406966
Sadiya A
; Ahmed SM
; Carlsson M
; Tesfa Y
; George M
; Ali SH
; Siddieg HH
; Abusnana S
Eur J Clin Nutr
2015[Jun]; 69
(6
): 707-11
PMID25406966
show ga
OBJECTIVES: To study the effect of Vitamin D3 supplementation on metabolic
control in an obese type 2 diabetes Emirati population. METHODS: This randomized
double-blind clinical trial was conducted with 87 vitamin D-deficient obese, type
2 diabetic participants. The vitamin D-group (n=45) and the placebo group (n=42)
were matched for gender, age, HbA1c and 25-hydroxy vitamin D (25(OH) D) at the
baseline. The study was divided into two phases of 3 months each; in phase 1, the
vitamin D-group received 6000?IU vitamin D3/day followed by 3000?IU vitamin
D3/day in phase 2, whereas the placebo group (n=42) received matching placebo.
RESULTS: After supplementation, serum 25(OH) D peaked in the vitamin D-group in
phase 1 (77.2±30.1?nmol/l, P=0.003) followed by a decrease in the phase 2
(61.4±18.8?nmol/l, P=0.006), although this was higher compared with baseline. In
the placebo group, no difference was observed in the serum 25(OH) D levels
throughout the intervention. Relative to baseline serum, parathyroid hormone
decreased 24% (P=0.003) in the vitamin D-group in phase 2, but remained unchanged
in the placebo group. No significant changes were observed in blood pressure,
fasting blood glucose, HbA1c, C-peptide, creatinine, phosphorous, alkaline
phosphatase, lipids, C-reactive protein or thyroid stimulating hormone
concentrations compared with baseline in either group. CONCLUSIONS: Six months of
vitamin D3 supplementation to vitamin D-deficient obese type 2 diabetes patients
in the UAE normalized the vitamin D status and reduced the incidence of
eucalcemic parathyroid hormone elevation but showed no effect on the metabolic
control.
|*Dietary Supplements/adverse effects
[MESH]
|Adult
[MESH]
|Body Mass Index
[MESH]
|Calcifediol/blood
[MESH]
|Cholecalciferol/administration & dosage/adverse effects/*therapeutic use
[MESH]
|Diabetes Mellitus, Type 2/*complications
[MESH]
|Double-Blind Method
[MESH]
|Female
[MESH]
|Glycated Hemoglobin/analysis
[MESH]
|Humans
[MESH]
|Hyperparathyroidism, Secondary/epidemiology/etiology/*prevention & control
[MESH]