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10.4239/wjd.v6.i5.726 http://scihub22266oqcxt.onion/10.4239/wjd.v6.i5.726 C4458501!4458501!26069721     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       World+J+Diabetes 2015 ; 6 (5): 726-33 Nephropedia Template TP {{tp|p=26069721|t=2015. Functions of Müller cell-derived vascular endothelial growth factor in diabetic retinopathy |pdf=|usr=}}{{26069721}} gab.com Text Functions of Müller cell-derived vascular endothelial growth factor in diabetic retinopathy JO: World J Diabetes http://www.kidney.de/pget.php?&tw=1&pmid=26069721 #FOAvip Müller cells are macroglia and play many essential roles as supporting cells in the retina. To respond to pathological changes in diabetic retinopathy (DR), a major complication in the eye of diabetic patients, retinal Müller glia produce a high level of vascular endothelial growth factor (VEGF or VEGF-A). As VEGF is expressed by multiple retinal cell-types and Müller glia comprise only a small portion of cells in the retina, it has been a great challenge to reveal the function of VEGF or other globally expressed proteins produced by Müller cells. With the development of conditional gene targeting tools, it is now possible to dissect the function of Müller cell-derived VEGF in vivo. By using conditional gene targeting approach, we demonstrate that Müller glia are a major source of retinal VEGF in diabetic mice and Müller cell-derived VEGF plays a significant role in the alteration of protein expression and peroxynitration, which leads to retinal inflammation, neovascularization, vascular leakage, and vascular lesion, key pathological changes in DR. Therefore, Müller glia are a potential cellular target for the treatment of DR, a leading cause of blindness. Twit Text FOAVip Functions of Müller cell-derived vascular endothelial growth factor in diabetic retinopathy ????World J Diabetes http://www.kidney.de/pget.php?&tw=1&pmid=26069721 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26069721 #FOAvip English Wikipedia <ref>{{Cite pmid|26069721}}</ref> Functions of Müller cell-derived vascular endothelial growth factor in diabetic retinopathy #MMPMID26069721 Wang JJ; Zhu M; Le YZ World J Diabetes 2015[Jun]; 6 (5): 726-33 PMID26069721show ga Müller cells are macroglia and play many essential roles as supporting cells in the retina. To respond to pathological changes in diabetic retinopathy (DR), a major complication in the eye of diabetic patients, retinal Müller glia produce a high level of vascular endothelial growth factor (VEGF or VEGF-A). As VEGF is expressed by multiple retinal cell-types and Müller glia comprise only a small portion of cells in the retina, it has been a great challenge to reveal the function of VEGF or other globally expressed proteins produced by Müller cells. With the development of conditional gene targeting tools, it is now possible to dissect the function of Müller cell-derived VEGF in vivo. By using conditional gene targeting approach, we demonstrate that Müller glia are a major source of retinal VEGF in diabetic mice and Müller cell-derived VEGF plays a significant role in the alteration of protein expression and peroxynitration, which leads to retinal inflammation, neovascularization, vascular leakage, and vascular lesion, key pathological changes in DR. Therefore, Müller glia are a potential cellular target for the treatment of DR, a leading cause of blindness. äFunctions of Müller cell-derived vascular endothelial growth factor in(epmc).pdf DeepDyve Pubget Overpricing