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10.4049/jimmunol.1402154 http://scihub22266oqcxt.onion/10.4049/jimmunol.1402154 C4458460!4458460!25926673     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25926673&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25926673.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Immunol 2015 ; 194 (12): 5872-84 Nephropedia Template TP {{tp|p=25926673|t=2015. iNKT cells require autophagy to coordinate proliferation and survival signals during differentiation |pdf=|usr=}}{{25926673}} gab.com Text iNKT cells require autophagy to coordinate proliferation and survival signals during differentiation JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25926673 #FOAvip Autophagy regulates cell differentiation, proliferation and survival in multiple cell types, including cells of the immune system. Herein we examined the effects of a disruption of autophagy on the differentiation of invariant natural killer T cells (iNKT cells). Using mice with a T lymphocyte specific deletion of Atg5 or Atg7,two members of the macroautophagic pathway, we observed a profound decrease in the iNKT cell population. The deficit is cell-autonomous, and it acts predominantly to reduce the number of mature cells, as well as the function of peripheral iNKT cells. In the absence of autophagy, there is reduced progression of iNKT cells in the thymus through the cell cycle, as well as increased apoptosis of these cells. Importantly, the reduction in Th1-biased iNKT cells is most pronounced, leading to a selective reduction in iNKT cell derived IFN?. Our findings highlight the unique metabolic and genetic requirements for the differentiation of iNKT cells. Twit Text FOAVip iNKT cells require autophagy to coordinate proliferation and survival signals during differentiation ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25926673 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25926673 #FOAvip English Wikipedia <ref>{{Cite pmid|25926673}}</ref> iNKT cells require autophagy to coordinate proliferation and survival signals during differentiation #MMPMID25926673 Pei B; Zhao M; Miller BC; Véla JL; Bruinsma MW; Virgin HW; Kronenberg M J Immunol 2015[Jun]; 194 (12): 5872-84 PMID25926673show ga Autophagy regulates cell differentiation, proliferation and survival in multiple cell types, including cells of the immune system. Herein we examined the effects of a disruption of autophagy on the differentiation of invariant natural killer T cells (iNKT cells). Using mice with a T lymphocyte specific deletion of Atg5 or Atg7,two members of the macroautophagic pathway, we observed a profound decrease in the iNKT cell population. The deficit is cell-autonomous, and it acts predominantly to reduce the number of mature cells, as well as the function of peripheral iNKT cells. In the absence of autophagy, there is reduced progression of iNKT cells in the thymus through the cell cycle, as well as increased apoptosis of these cells. Importantly, the reduction in Th1-biased iNKT cells is most pronounced, leading to a selective reduction in iNKT cell derived IFN?. Our findings highlight the unique metabolic and genetic requirements for the differentiation of iNKT cells. äiNKT cells require autophagy to coordinate proliferation and survival (epmc).pdf DeepDyve Pubget Overpricing