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10.1007/s12079-015-0260-3 http://scihub22266oqcxt.onion/10.1007/s12079-015-0260-3 C4458252!4458252!25645979     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cell+Commun+Signal 2015 ; 9 (2): 151-8 Nephropedia Template TP {{tp|p=25645979|t=2015. IGFBP-2 and ?5: important regulators of normal and neoplastic mammary gland physiology |pdf=|usr=}}{{25645979}} gab.com Text IGFBP-2 and 5: important regulators of normal and neoplastic mammary gland physiology JO: J Cell Commun Signal http://www.kidney.de/pget.php?&tw=1&pmid=25645979 #FOAvip The insulin-like growth factor (IGF) axis plays an important role in mammary gland physiology. In addition, dysregulation of this molecular axis may have a causal role in the aetiology and development of breast cancer (BC). This report discusses the IGF axis in normal and neoplastic mammary gland with special reference to IGF binding proteins (IGFBPs) -2 and ?5. We describe how these high affinity binders of IGF-1 and IGF-2 may regulate local actions of growth factors in an autocrine and/or paracrine manner and how they also have IGF-independent effects in mammary gland. We discuss clinical studies which investigate both the prognostic value of IGFBP-2 and ?5 expression in BC and possible involvement of these genes in the development of resistance to adjuvant endocrine therapies. Twit Text FOAVip IGFBP-2 and 5: important regulators of normal and neoplastic mammary gland physiology ????J Cell Commun Signal http://www.kidney.de/pget.php?&tw=1&pmid=25645979 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25645979 #FOAvip English Wikipedia <ref>{{Cite pmid|25645979}}</ref> IGFBP-2 and ?5: important regulators of normal and neoplastic mammary gland physiology #MMPMID25645979 Beattie J; Hawsawi Y; Alkharobi H; El-Gendy R J Cell Commun Signal 2015[Jun]; 9 (2): 151-8 PMID25645979show ga The insulin-like growth factor (IGF) axis plays an important role in mammary gland physiology. In addition, dysregulation of this molecular axis may have a causal role in the aetiology and development of breast cancer (BC). This report discusses the IGF axis in normal and neoplastic mammary gland with special reference to IGF binding proteins (IGFBPs) -2 and ?5. We describe how these high affinity binders of IGF-1 and IGF-2 may regulate local actions of growth factors in an autocrine and/or paracrine manner and how they also have IGF-independent effects in mammary gland. We discuss clinical studies which investigate both the prognostic value of IGFBP-2 and ?5 expression in BC and possible involvement of these genes in the development of resistance to adjuvant endocrine therapies. äIGFBP-2 and ?5: important regulators of normal and neoplastic mammary (epmc).pdf DeepDyve Pubget Overpricing