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10.1016/j.molcel.2015.03.031 http://scihub22266oqcxt.onion/10.1016/j.molcel.2015.03.031 C4458219!4458219!25936801     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Cell 2015 ; 58 (5): 743-54 Nephropedia Template TP {{tp|p=25936801|t=2015. Cancer/testis antigen PASD1 silences the circadian clock |pdf=|usr=}}{{25936801}} gab.com Text Cancer/testis antigen PASD1 silences the circadian clock JO: Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=25936801 #FOAvip The circadian clock orchestrates global changes in transcriptional regulation on a daily basis via the bHLH-PAS transcription factor CLOCK:BMAL1. Pathways driven by other bHLH-PAS transcription factors have a homologous repressor that modulates activity on a tissue-specific basis, but none have been identified for CLOCK:BMAL1. We show here that the cancer/testis antigen PASD1 fulfills this role to suppress circadian rhythms. PASD1 is evolutionarily related to CLOCK and interacts with the CLOCK:BMAL1 complex to repress transcriptional activation. Expression of PASD1 is restricted to germline tissues in healthy individuals, but can be induced in cells of somatic origin upon oncogenic transformation. Reducing PASD1 in human cancer cells significantly increases the amplitude of transcriptional oscillations to generate more robust circadian rhythms. Our results describe a function for a germline-specific protein in regulation of the circadian clock and provide a molecular link from oncogenic transformation to suppression of circadian rhythms. Twit Text FOAVip Cancer/testis antigen PASD1 silences the circadian clock ????Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=25936801 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25936801 #FOAvip English Wikipedia <ref>{{Cite pmid|25936801}}</ref> Cancer/testis antigen PASD1 silences the circadian clock #MMPMID25936801 Michael AK; Harvey SL; Sammons PJ; Anderson AP; Kopalle HM; Banham AH; Partch CL Mol Cell 2015[Jun]; 58 (5): 743-54 PMID25936801show ga The circadian clock orchestrates global changes in transcriptional regulation on a daily basis via the bHLH-PAS transcription factor CLOCK:BMAL1. Pathways driven by other bHLH-PAS transcription factors have a homologous repressor that modulates activity on a tissue-specific basis, but none have been identified for CLOCK:BMAL1. We show here that the cancer/testis antigen PASD1 fulfills this role to suppress circadian rhythms. PASD1 is evolutionarily related to CLOCK and interacts with the CLOCK:BMAL1 complex to repress transcriptional activation. Expression of PASD1 is restricted to germline tissues in healthy individuals, but can be induced in cells of somatic origin upon oncogenic transformation. Reducing PASD1 in human cancer cells significantly increases the amplitude of transcriptional oscillations to generate more robust circadian rhythms. Our results describe a function for a germline-specific protein in regulation of the circadian clock and provide a molecular link from oncogenic transformation to suppression of circadian rhythms. äCancer/testis antigen PASD1 silences the circadian clock (epmc).pdf DeepDyve Pubget Overpricing