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2015 ; 107
(4
): 271-6
Nephropedia Template TP
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English Wikipedia
Cost savings of human milk as a strategy to reduce the incidence of necrotizing
enterocolitis in very low birth weight infants
#MMPMID25765818
Johnson TJ
; Patel AL
; Bigger HR
; Engstrom JL
; Meier PP
Neonatology
2015[]; 107
(4
): 271-6
PMID25765818
show ga
BACKGROUND: Necrotizing enterocolitis (NEC) is a costly morbidity in very low
birth weight (VLBW; <1,500 g birth weight) infants that increases hospital length
of stay and requires expensive treatments. OBJECTIVES: To evaluate the cost of
NEC as a function of dose and exposure period of human milk (HM) feedings
received by VLBW infants during the neonatal intensive care unit (NICU)
hospitalization and determine the drivers of differences in NICU hospitalization
costs for infants with and without NEC. METHODS: This study included 291 VLBW
infants enrolled in an NIH-funded prospective observational cohort study between
February 2008 and July 2012. We examined the incidence of NEC, NICU
hospitalization cost, and cost of individual resources used during the NICU
hospitalization. RESULTS: Twenty-nine (10.0%) infants developed NEC. The average
total NICU hospitalization cost (in 2012 USD) was USD 180,163 for infants with
NEC and USD 134,494 for infants without NEC (p = 0.024). NEC was associated with
a marginal increase in costs of USD 43,818, after controlling for demographic
characteristics, risk of NEC, and average daily dose of HM during days 1-14 (p <
0.001). Each additional ml/kg/day of HM during days 1-14 decreased
non-NEC-related NICU costs by USD 534 (p < 0.001). CONCLUSIONS: Avoidance of
formula and use of exclusive HM feedings during the first 14 days of life is an
effective strategy to reduce the risk of NEC and resulting NICU costs in VLBW
infants. Hospitals investing in initiatives to feed exclusive HM during the first
14 days of life could substantially reduce NEC-related NICU hospitalization
costs.
|*Cost Savings
[MESH]
|*Infant, Very Low Birth Weight
[MESH]
|*Milk, Human
[MESH]
|Birth Weight
[MESH]
|Enterocolitis, Necrotizing/economics/*prevention & control
[MESH]