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10.1016/j.stem.2015.04.002 http://scihub22266oqcxt.onion/10.1016/j.stem.2015.04.002 C4458197!4458197 !25936916     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25936916 &cmd=llinks): Failed to open stream: HTTP request failed! 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An Apela RNA-Containing Negative Feedback Loop Regulates p53-Mediated Apoptosis in Embryonic Stem Cells |pdf=|usr=}}{{25936916 }} gab.com Text An Apela RNA-Containing Negative Feedback Loop Regulates p53-Mediated Apoptosis in Embryonic Stem Cells JO: Cell Stem Cell http://www.kidney.de/pget.php?&tw=1&pmid=25936916 #FOAvip Maintaining genomic integrity is of paramount importance to embryonic stem cells (ESCs), as mutations are readily propagated to daughter cells. ESCs display hypersensitivity to DNA damage-induced apoptosis (DIA) to prevent such propagation, although the molecular mechanisms underlying this apoptotic response are unclear. Here, we report that the regulatory RNA Apela positively regulates p53-mediated DIA. Apela is highly expressed in mouse ESCs and is repressed by p53 activation, and Apela depletion compromises p53-dependent DIA. Although Apela contains a coding region, this coding ability is dispensable for Apela's role in p53-mediated DIA. Instead, Apela functions as a regulatory RNA and interacts with hnRNPL, which prevents the mitochondrial localization and activation of p53. Together, these results describe a tri-element negative feedback loop composed of p53, Apela, and hnRNPL that regulates p53-mediated DIA, and they further demonstrate that regulatory RNAs add a layer of complexity to the apoptotic response of ESCs after DNA damage. Twit Text FOAVip An Apela RNA-Containing Negative Feedback Loop Regulates p53-Mediated Apoptosis in Embryonic Stem Cells ????Cell Stem Cell http://www.kidney.de/pget.php?&tw=1&pmid=25936916 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25936916 #FOAvip English Wikipedia <ref>{{Cite pmid|25936916 }}</ref> An Apela RNA-Containing Negative Feedback Loop Regulates p53-Mediated Apoptosis in Embryonic Stem Cells #MMPMID25936916 Li M ; Gou H ; Tripathi BK ; Huang J ; Jiang S ; Dubois W ; Waybright T ; Lei M ; Shi J ; Zhou M ; Huang J Cell Stem Cell 2015[Jun]; 16 (6 ): 669-83 PMID25936916 show ga Maintaining genomic integrity is of paramount importance to embryonic stem cells (ESCs), as mutations are readily propagated to daughter cells. ESCs display hypersensitivity to DNA damage-induced apoptosis (DIA) to prevent such propagation, although the molecular mechanisms underlying this apoptotic response are unclear. Here, we report that the regulatory RNA Apela positively regulates p53-mediated DIA. Apela is highly expressed in mouse ESCs and is repressed by p53 activation, and Apela depletion compromises p53-dependent DIA. Although Apela contains a coding region, this coding ability is dispensable for Apela's role in p53-mediated DIA. Instead, Apela functions as a regulatory RNA and interacts with hnRNPL, which prevents the mitochondrial localization and activation of p53. Together, these results describe a tri-element negative feedback loop composed of p53, Apela, and hnRNPL that regulates p53-mediated DIA, and they further demonstrate that regulatory RNAs add a layer of complexity to the apoptotic response of ESCs after DNA damage. |*Apoptosis/genetics [MESH] |*Feedback, Physiological [MESH] |3' Untranslated Regions/genetics [MESH] |Amino Acid Sequence [MESH] |Animals [MESH] |Base Sequence [MESH] |DNA Damage [MESH] |Enhancer Elements, Genetic/genetics [MESH] |Genetic Loci [MESH] |Heterogeneous-Nuclear Ribonucleoproteins/chemistry/metabolism [MESH] |Mice [MESH] |Mitochondria/metabolism [MESH] |Molecular Sequence Data [MESH] |Mouse Embryonic Stem Cells/*cytology/*metabolism [MESH] |Open Reading Frames/genetics [MESH] |Protein Binding/genetics [MESH] |RNA/*metabolism [MESH]An Apela RNA-Containing Negative Feedback Loop Regulates p53-Mediated (epmc).pdf DeepDyve Pubget Overpricing