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10.1016/j.stem.2015.04.001 http://scihub22266oqcxt.onion/10.1016/j.stem.2015.04.001 C4458159!4458159!25936917     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Stem+Cell 2015 ; 16 (6): 653-68 Nephropedia Template TP {{tp|p=25936917|t=2015. Tex10 Coordinates Epigenetic Control of Super-Enhancer Activity in Pluripotency and Reprogramming |pdf=|usr=}}{{25936917}} gab.com Text Tex10 Coordinates Epigenetic Control of Super-Enhancer Activity in Pluripotency and Reprogramming JO: Cell Stem Cell http://www.kidney.de/pget.php?&tw=1&pmid=25936917 #FOAvip Super-enhancers (SEs) are large clusters of transcriptional enhancers that are co-occupied by multiple lineage specific transcription factors driving expression of genes that define cell identity. In embryonic stem cells (ESCs), SEs are highly enriched for the core pluripotency factors Oct4, Sox2, and Nanog. In this study, we sought to dissect the molecular control mechanism of SE activity in pluripotency and reprogramming. Starting from a protein interaction network surrounding Sox2, we identified Tex10 as a key pluripotency factor that plays a functionally significant role in ESC self-renewal, early embryo development, and reprogramming. Tex10 is enriched at SEs in a Sox2-dependent manner and coordinates histone acetylation and DNA demethylation at SEs. Tex10 activity is also important for pluripotency and reprogramming in human cells. Our study therefore highlights Tex10 as a core component of the pluripotency network and sheds light on its role in epigenetic control of SE activity for cell fate determination. Twit Text FOAVip Tex10 Coordinates Epigenetic Control of Super-Enhancer Activity in Pluripotency and Reprogramming ????Cell Stem Cell http://www.kidney.de/pget.php?&tw=1&pmid=25936917 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25936917 #FOAvip English Wikipedia <ref>{{Cite pmid|25936917}}</ref> Tex10 Coordinates Epigenetic Control of Super-Enhancer Activity in Pluripotency and Reprogramming #MMPMID25936917 Ding J; Huang X; Shao N; Zhou H; Lee DF; Faiola F; Fidalgo M; Guallar D; Saunders A; Shliaha PV; Wang H; Waghray A; Papatsenko D; Sánchez-Priego C; Li D; Yuan Y; Lemischka IR; Shen L; Kelley K; Deng H; Shen X; Wang J Cell Stem Cell 2015[Jun]; 16 (6): 653-68 PMID25936917show ga Super-enhancers (SEs) are large clusters of transcriptional enhancers that are co-occupied by multiple lineage specific transcription factors driving expression of genes that define cell identity. In embryonic stem cells (ESCs), SEs are highly enriched for the core pluripotency factors Oct4, Sox2, and Nanog. In this study, we sought to dissect the molecular control mechanism of SE activity in pluripotency and reprogramming. Starting from a protein interaction network surrounding Sox2, we identified Tex10 as a key pluripotency factor that plays a functionally significant role in ESC self-renewal, early embryo development, and reprogramming. Tex10 is enriched at SEs in a Sox2-dependent manner and coordinates histone acetylation and DNA demethylation at SEs. Tex10 activity is also important for pluripotency and reprogramming in human cells. Our study therefore highlights Tex10 as a core component of the pluripotency network and sheds light on its role in epigenetic control of SE activity for cell fate determination. äTex10 Coordinates Epigenetic Control of Super-Enhancer Activity in Plu(epmc).pdf DeepDyve Pubget Overpricing