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10.1038/nm.3856 http://scihub22266oqcxt.onion/10.1038/nm.3856 C4458139!4458139!25962123     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Med 2015 ; 21 (6): 591-600 Nephropedia Template TP {{tp|p=25962123|t=2015. Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells |pdf=|usr=}}{{25962123}} gab.com Text Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells JO: Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=25962123 #FOAvip Infection with hepatitis B virus (HBV) results in disparate degrees of tissue injury: it can replicate without pathological consequences or trigger immune-mediated necroinflammatory liver damage. We investigated the potential for myeloid-derived suppressor cells (MDSC) to suppress T cell-mediated immunopathology in this setting. Granulocytic MDSC (gMDSC) expanded transiently in acute resolving HBV, decreasing before peak hepatic injury. In persistent infection, arginase-expressing gMDSC (and circulating arginase) increased most in phases characterized by HBV replication without immunopathology, whilst L-arginine decreased. gMDSC expressed liver-homing chemokine receptors and accumulated in the liver, their expansion being supported by hepatic stellate cells. We provide in vitro and ex vivo evidence that gMDSC potently inhibited T cells in a partially arginase-dependent manner. L-arginine-deprived T cells upregulated system-L amino acid transporters to increase uptake of essential nutrients and attempt metabolic reprogramming. These data demonstrate the capacity of expanded arginase-expressing gMDSC to regulate liver immunopathology in HBV infection. Twit Text FOAVip Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells ????Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=25962123 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25962123 #FOAvip English Wikipedia <ref>{{Cite pmid|25962123}}</ref> Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells #MMPMID25962123 Pallett LJ; Gill US; Quaglia A; Sinclair LV; Jover-Cobos M; Schurich A; Singh KP; Thomas N; Das A; Chen A; Fusai G; Bertoletti A; Cantrell DA; Kennedy PT; Davies NA; Haniffa M; Maini MK Nat Med 2015[Jun]; 21 (6): 591-600 PMID25962123show ga Infection with hepatitis B virus (HBV) results in disparate degrees of tissue injury: it can replicate without pathological consequences or trigger immune-mediated necroinflammatory liver damage. We investigated the potential for myeloid-derived suppressor cells (MDSC) to suppress T cell-mediated immunopathology in this setting. Granulocytic MDSC (gMDSC) expanded transiently in acute resolving HBV, decreasing before peak hepatic injury. In persistent infection, arginase-expressing gMDSC (and circulating arginase) increased most in phases characterized by HBV replication without immunopathology, whilst L-arginine decreased. gMDSC expressed liver-homing chemokine receptors and accumulated in the liver, their expansion being supported by hepatic stellate cells. We provide in vitro and ex vivo evidence that gMDSC potently inhibited T cells in a partially arginase-dependent manner. L-arginine-deprived T cells upregulated system-L amino acid transporters to increase uptake of essential nutrients and attempt metabolic reprogramming. These data demonstrate the capacity of expanded arginase-expressing gMDSC to regulate liver immunopathology in HBV infection. äMetabolic regulation of hepatitis B immunopathology by myeloid-derived(epmc).pdf DeepDyve Pubget Overpricing