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10.1007/s11523-014-0333-x http://scihub22266oqcxt.onion/10.1007/s11523-014-0333-x C4457933!4457933 !25213039     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25213039 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Target+Oncol 2015 ; 10 (2 ): 199-213 Nephropedia Template TP {{tp|p=25213039 |t=2015. Regorafenib as a single-agent in the treatment of patients with gastrointestinal tumors: an overview for pharmacists |pdf=|usr=}}{{25213039 }} gab.com Text Regorafenib as a single-agent in the treatment of patients with gastrointestinal tumors: an overview for pharmacists JO: Target Oncol http://www.kidney.de/pget.php?&tw=1&pmid=25213039 #FOAvip Regorafenib (BAY 73-4506, StivargaŽ Bayer HealthCare Pharmaceutical Inc) is an oral multikinase inhibitor with a distinct and wide-ranging profile of tyrosine kinase inhibition, resulting in antiangiogenic and antiproliferative properties in tumors. Single-agent regorafenib administered as a 160-mg daily dose for the first 21 days of a 28-day cycle is approved for use in patients with pretreated metastatic colorectal cancer (mCRC) and gastrointestinal stromal tumor (GIST) progressing on imatinib and sunitinib, following publication of data from the phase III CORRECT and GRID studies respectively. Regorafenib is currently under phase III investigation in patients with hepatocellular carcinoma and is in several phase II studies in patients with gastrointestinal (GI) tumors. This review describes the clinical development of regorafenib in patients with GI cancers, and highlights the key issues important for the modern day clinical pharmacist who forms part of the multidisciplinary team ensuring safe and effective delivery of the drug to the patient. This information is considered of particular importance to the clinical pharmacist for the future development of regorafenib in this treatment setting. Twit Text FOAVip Regorafenib as a single-agent in the treatment of patients with gastrointestinal tumors: an overview for pharmacists ????Target Oncol http://www.kidney.de/pget.php?&tw=1&pmid=25213039 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25213039 #FOAvip English Wikipedia <ref>{{Cite pmid|25213039 }}</ref> Regorafenib as a single-agent in the treatment of patients with gastrointestinal tumors: an overview for pharmacists #MMPMID25213039 Rey JB ; Launay-Vacher V ; Tournigand C Target Oncol 2015[Jun]; 10 (2 ): 199-213 PMID25213039 show ga Regorafenib (BAY 73-4506, StivargaŽ Bayer HealthCare Pharmaceutical Inc) is an oral multikinase inhibitor with a distinct and wide-ranging profile of tyrosine kinase inhibition, resulting in antiangiogenic and antiproliferative properties in tumors. Single-agent regorafenib administered as a 160-mg daily dose for the first 21 days of a 28-day cycle is approved for use in patients with pretreated metastatic colorectal cancer (mCRC) and gastrointestinal stromal tumor (GIST) progressing on imatinib and sunitinib, following publication of data from the phase III CORRECT and GRID studies respectively. Regorafenib is currently under phase III investigation in patients with hepatocellular carcinoma and is in several phase II studies in patients with gastrointestinal (GI) tumors. This review describes the clinical development of regorafenib in patients with GI cancers, and highlights the key issues important for the modern day clinical pharmacist who forms part of the multidisciplinary team ensuring safe and effective delivery of the drug to the patient. This information is considered of particular importance to the clinical pharmacist for the future development of regorafenib in this treatment setting. |*Pharmacists [MESH] |Animals [MESH] |Drug Interactions [MESH] |Gastrointestinal Neoplasms/*drug therapy/enzymology/pathology [MESH] |Humans [MESH] |Phenylurea Compounds/adverse effects/pharmacokinetics/*therapeutic use [MESH] |Protein Kinase Inhibitors/adverse effects/pharmacokinetics/*therapeutic use [MESH] |Pyridines/adverse effects/pharmacokinetics/*therapeutic use [MESH] |Signal Transduction/drug effects [MESH]Regorafenib as a single-agent in the treatment of patients with gastro(epmc).pdf DeepDyve Pubget Overpricing