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10.1016/j.alcohol.2014.09.034

http://scihub22266oqcxt.onion/10.1016/j.alcohol.2014.09.034
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C4457686!4457686!25641765
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suck abstract from ncbi


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pmid25641765      Alcohol 2015 ; 49 (4): 341-9
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  • Circadian Clock Genes: Effects on Dopamine, Reward and Addiction #MMPMID25641765
  • Parekh PK; Ozburn AR; McClung CA
  • Alcohol 2015[Jun]; 49 (4): 341-9 PMID25641765show ga
  • Addiction is a widespread public health issue with social and economic ramifications. Substance abuse disorders are often accompanied by disruptions in circadian rhythms including sleep/wake cycles, which can exacerbate symptoms of addiction and dependence. Additionally, genetic disturbance of circadian molecular mechanisms can predispose some individuals to substance abuse disorders. In this review, we will discuss how circadian genes can regulate midbrain dopaminergic activity and subsequently, drug intake and reward. We will also suggest future directions for research on circadian genes and drugs of abuse.
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