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10.1042/BJ20101500 http://scihub22266oqcxt.onion/10.1042/BJ20101500 C4457510!4457510!21585337     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 286.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 286.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochem+J 2011 ; 437 (3): 515-20 Nephropedia Template TP {{tp|p=21585337|t=2011. Transforming Growth Factor-?2 promotes Snail-mediated endothelial-mesenchymal transition through convergence of Smad-dependent and Smad-independent signaling |pdf=|usr=}}{{21585337}} gab.com Text Transforming Growth Factor- 2 promotes Snail-mediated endothelial-mesenchymal transition through convergence of Smad-dependent and Smad-independent signaling JO: Biochem J http://www.kidney.de/pget.php?&tw=1&pmid=21585337 #FOAvip Endothelial-mesenchymal transition (EndMT) is a critical process of cardiac development and disease progression. However, little is know about the signaling mechanisms that cause endothelial cells to transform into mesenchymal cells. Here we show that transforming growth factor-beta2 (TGF-?2) stimulates EndMT through Smad, MEK, PI3K, and p38 MAPK signaling pathways. Inhibitors of these pathways prevent TGF-?2-induced EndMT. Furthermore, we show that all of these pathways are essential for increasing expression of the cell adhesion suppressing transcription factor Snail. Inhibition of Snail with siRNA prevents TGF-?2-induced EndMT. However, over-expression of Snail is not sufficient to cause EndMT. Chemical inhibition of GSK-3? allows EndMT to be induced by Snail over-expression. Expression of a mutant Snail protein that is resistant to GSK-3?-dependent inactivation also promotes EndMT. These data provide the foundation for understanding the roles of specific signaling pathways in mediating EndMT. Twit Text FOAVip Transforming Growth Factor- 2 promotes Snail-mediated endothelial-mesenchymal transition through convergence of Smad-dependent and Smad-independent signaling ????Biochem J http://www.kidney.de/pget.php?&tw=1&pmid=21585337 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21585337 #FOAvip English Wikipedia <ref>{{Cite pmid|21585337}}</ref> Transforming Growth Factor-?2 promotes Snail-mediated endothelial-mesenchymal transition through convergence of Smad-dependent and Smad-independent signaling #MMPMID21585337 Medici D; Potenta S; Kalluri R Biochem J 2011[Aug]; 437 (3): 515-20 PMID21585337show ga Endothelial-mesenchymal transition (EndMT) is a critical process of cardiac development and disease progression. However, little is know about the signaling mechanisms that cause endothelial cells to transform into mesenchymal cells. Here we show that transforming growth factor-beta2 (TGF-?2) stimulates EndMT through Smad, MEK, PI3K, and p38 MAPK signaling pathways. Inhibitors of these pathways prevent TGF-?2-induced EndMT. Furthermore, we show that all of these pathways are essential for increasing expression of the cell adhesion suppressing transcription factor Snail. Inhibition of Snail with siRNA prevents TGF-?2-induced EndMT. However, over-expression of Snail is not sufficient to cause EndMT. Chemical inhibition of GSK-3? allows EndMT to be induced by Snail over-expression. Expression of a mutant Snail protein that is resistant to GSK-3?-dependent inactivation also promotes EndMT. These data provide the foundation for understanding the roles of specific signaling pathways in mediating EndMT. äTransforming Growth Factor-?2 promotes Snail-mediated endothelial-mese(epmc).pdf DeepDyve Pubget Overpricing