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10.14800/ics.161

http://scihub22266oqcxt.onion/10.14800/ics.161
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C4457461!4457461!26052543
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suck abstract from ncbi


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pmid26052543      Inflamm+Cell+Signal 2014 ; 1 (4): ä
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  • Monoamine oxidase A (MAO-A): a signature marker of alternatively activated monocytes/macrophages #MMPMID26052543
  • Cathcart MK; Bhattacharjee A
  • Inflamm Cell Signal 2014[]; 1 (4): ä PMID26052543show ga
  • Monocytes/macrophages are versatile cells centrally involved in host defense and immunity. Th1 cytokines induce a classical activation program in monocytes/macrophages leading to a proinflammatory M1 macrophage phenotype while Th2 cytokines IL-4 and IL-13 promote monocyte differentiation into an alternatively activated, anti-inflammatory M2 macrophage phenotype. Although monoamine oxidase A (MAO-A) is primarily known for its action in the nervous system, several recent studies have identified MAO-A as a signature marker of alternative activation of monocytes/macrophages. In this brief review we explore the signaling pathways/molecules that regulate MAO-A expression in alternatively activated monocytes/macrophages. We further discuss the contribution of MAO-A to the resolution of inflammation and identify potential therapeutic targets for controlling inflammation. Altogether this review provides deeper insight into the role of MAO-A in alternative activation of monocytes/macrophages and their participation in the inflammatory response.
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