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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Neural+Eng
2015 ; 12
(3
): 036009
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A high performing brain-machine interface driven by low-frequency local field
potentials alone and together with spikes
#MMPMID25946198
Stavisky SD
; Kao JC
; Nuyujukian P
; Ryu SI
; Shenoy KV
J Neural Eng
2015[Jun]; 12
(3
): 036009
PMID25946198
show ga
OBJECTIVE: Brain-machine interfaces (BMIs) seek to enable people with movement
disabilities to directly control prosthetic systems with their neural activity.
Current high performance BMIs are driven by action potentials (spikes), but
access to this signal often diminishes as sensors degrade over time. Decoding
local field potentials (LFPs) as an alternative or complementary BMI control
signal may improve performance when there is a paucity of spike signals. To date
only a small handful of LFP decoding methods have been tested online; there
remains a need to test different LFP decoding approaches and improve LFP-driven
performance. There has also not been a reported demonstration of a hybrid BMI
that decodes kinematics from both LFP and spikes. Here we first evaluate a BMI
driven by the local motor potential (LMP), a low-pass filtered time-domain LFP
amplitude feature. We then combine decoding of both LMP and spikes to implement a
hybrid BMI. APPROACH: Spikes and LFP were recorded from two macaques implanted
with multielectrode arrays in primary and premotor cortex while they performed a
reaching task. We then evaluated closed-loop BMI control using biomimetic
decoders driven by LMP, spikes, or both signals together. MAIN RESULTS: LMP
decoding enabled quick and accurate cursor control which surpassed previously
reported LFP BMI performance. Hybrid decoding of both spikes and LMP improved
performance when spikes signal quality was mediocre to poor. SIGNIFICANCE: These
findings show that LMP is an effective BMI control signal which requires minimal
power to extract and can substitute for or augment impoverished spikes signals.
Use of this signal may lengthen the useful lifespan of BMIs and is therefore an
important step towards clinically viable BMIs.