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10.14800/ics.285 http://scihub22266oqcxt.onion/10.14800/ics.285 C4457387!4457387!26052544     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26052544&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 500 Internal Server Error in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Inflamm+Cell+Signal 2014 ; 1 (5): e285- Nephropedia Template TP {{tp|p=26052544|t=2014. MFG-E8, a novel homeostatic regulator of osteoclastogenesis |pdf=|usr=}}{{26052544}} gab.com Text MFG-E8, a novel homeostatic regulator of osteoclastogenesis JO: Inflamm Cell Signal http://www.kidney.de/pget.php?&tw=1&pmid=26052544 #FOAvip Although the glycoprotein MFG-E8 (milk fat globule-epidermal growth factor-factor 8) has been investigated extensively as an anti-inflammatory and homeostatic molecule, a possible role in bone homeostasis and disease was not addressed until recently. Our group has now shown that MFG-E8 is expressed by human and mouse osteoclasts and regulates their differentiation and function (Abe et al., J Immunol 2014;193:1383?1391). Whereas genetic deficiency or antibody-mediated neutralization of MFG-E8 enhances osteoclastogenesis and promotes inflammation-induced bone loss in mice, local administration of recombinant MFG-E8 blocks bone loss. These findings establish MFG-E8 as a novel homeostatic regulator of osteoclastogenesis and suggest that MFG-E8 could be exploited therapeutically to treat disorders associated with inflammatory bone loss, such as periodontitis and rheumatoid arthritis. Twit Text FOAVip MFG-E8, a novel homeostatic regulator of osteoclastogenesis ????Inflamm Cell Signal http://www.kidney.de/pget.php?&tw=1&pmid=26052544 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26052544 #FOAvip English Wikipedia <ref>{{Cite pmid|26052544}}</ref> MFG-E8, a novel homeostatic regulator of osteoclastogenesis #MMPMID26052544 Hajishengallis G Inflamm Cell Signal 2014[]; 1 (5): e285- PMID26052544show ga Although the glycoprotein MFG-E8 (milk fat globule-epidermal growth factor-factor 8) has been investigated extensively as an anti-inflammatory and homeostatic molecule, a possible role in bone homeostasis and disease was not addressed until recently. Our group has now shown that MFG-E8 is expressed by human and mouse osteoclasts and regulates their differentiation and function (Abe et al., J Immunol 2014;193:1383?1391). Whereas genetic deficiency or antibody-mediated neutralization of MFG-E8 enhances osteoclastogenesis and promotes inflammation-induced bone loss in mice, local administration of recombinant MFG-E8 blocks bone loss. These findings establish MFG-E8 as a novel homeostatic regulator of osteoclastogenesis and suggest that MFG-E8 could be exploited therapeutically to treat disorders associated with inflammatory bone loss, such as periodontitis and rheumatoid arthritis. äMFG-E8, a novel homeostatic regulator of osteoclastogenesis (epmc).pdf DeepDyve Pubget Overpricing