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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Am+J+Med+Genet+C+Semin+Med+Genet
2011 ; 157C
(4
): 274-87
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
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English Wikipedia
Conjoined twins: a worldwide collaborative epidemiological study of the
International Clearinghouse for Birth Defects Surveillance and Research
#MMPMID22002822
Mutchinick OM
; Luna-Muñoz L
; Amar E
; Bakker MK
; Clementi M
; Cocchi G
; da Graça Dutra M
; Feldkamp ML
; Landau D
; Leoncini E
; Li Z
; Lowry B
; Marengo LK
; Martínez-Frías ML
; Mastroiacovo P
; Métneki J
; Morgan M
; Pierini A
; Rissman A
; Ritvanen A
; Scarano G
; Siffel C
; Szabova E
; Arteaga-Vázquez J
Am J Med Genet C Semin Med Genet
2011[Nov]; 157C
(4
): 274-87
PMID22002822
show ga
Conjoined twins (CT) are a very rare developmental accident of uncertain
etiology. Prevalence has been previously estimated to be 1 in 50,000 to 1 in
100,000 births. The process by which monozygotic twins do not fully separate but
form CT is not well understood. The purpose of the present study was to analyze
diverse epidemiological aspects of CT, including the different variables listed
in the Introduction Section of this issue of the Journal. The study was made
possible using the International Clearinghouse for Birth Defects Surveillance and
Research (ICBDSR) structure. This multicenter worldwide research includes the
largest sample of CT ever studied. A total of 383 carefully reviewed sets of CT
obtained from 26,138,837 births reported by 21 Clearinghouse Surveillance
Programs (SP) were included in the analysis. Total prevalence was 1.47 per
100,000 births (95% CI: 1.32-1.62). Salient findings including an evident
variation in prevalence among SPs: a marked variation in the type of pregnancy
outcome, a similarity in the proportion of CT types among programs: a significant
female predominance in CT: particularly of the thoracopagus type and a
significant male predominance in parapagus and parasitic types: significant
differences in prevalence by ethnicity and an apparent increasing prevalence
trend in South American countries. No genetic, environmental or demographic
significant associated factors were identified. Further work in epidemiology and
molecular research is necessary to understand the etiology and pathogenesis
involved in the development of this fascinating phenomenon of nature.