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10.1038/nrc2503 http://scihub22266oqcxt.onion/10.1038/nrc2503 C4457317!4457317!18813320     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=18813320&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Nat+Rev+Cancer 2008 ; 8 (10): 743-54 Nephropedia Template TP {{tp|p=18813320|t=2008. Basal cell carcinomas: attack of the hedgehog |pdf=|usr=}}{{18813320}} gab.com Text Basal cell carcinomas: attack of the hedgehog JO: Nat Rev Cancer http://www.kidney.de/pget.php?&tw=1&pmid=18813320 #FOAvip Basal cell carcinomas (BCCs) were essentially a molecular ?black box? until some 12 years ago, when identification of a genetic flaw in a rare subset of patients who have a great propensity to develop BCCs pointed to aberrant Hedgehog signalling as the pivotal defect leading to formation of these tumours. This discovery has facilitated a remarkable increase in our understanding of BCC carcinogenesis and has highlighted the carcinogenic role of this developmental pathway when aberrantly activated in adulthood. Importantly, a phase 1 first-in-human trial of a Hedgehog inhibitor has shown real progress in halting and even reversing the growth of these tumours. Twit Text FOAVip Basal cell carcinomas: attack of the hedgehog ????Nat Rev Cancer http://www.kidney.de/pget.php?&tw=1&pmid=18813320 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18813320 #FOAvip English Wikipedia <ref>{{Cite pmid|18813320}}</ref> Basal cell carcinomas: attack of the hedgehog #MMPMID18813320 Epstein EH Nat Rev Cancer 2008[Oct]; 8 (10): 743-54 PMID18813320show ga Basal cell carcinomas (BCCs) were essentially a molecular ?black box? until some 12 years ago, when identification of a genetic flaw in a rare subset of patients who have a great propensity to develop BCCs pointed to aberrant Hedgehog signalling as the pivotal defect leading to formation of these tumours. This discovery has facilitated a remarkable increase in our understanding of BCC carcinogenesis and has highlighted the carcinogenic role of this developmental pathway when aberrantly activated in adulthood. Importantly, a phase 1 first-in-human trial of a Hedgehog inhibitor has shown real progress in halting and even reversing the growth of these tumours. äBasal cell carcinomas: attack of the hedgehog (epmc).pdf DeepDyve Pubget Overpricing