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10.1242/jcs.161703 http://scihub22266oqcxt.onion/10.1242/jcs.161703 C4457156!4457156!25908852     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cell+Sci 2015 ; 128 (10): 1901-11 Nephropedia Template TP {{tp|p=25908852|t=2015. The nucleus is an intracellular propagator of tensile forces in NIH 3T3 fibroblasts |pdf=|usr=}}{{25908852}} gab.com Text The nucleus is an intracellular propagator of tensile forces in NIH 3T3 fibroblasts JO: J Cell Sci http://www.kidney.de/pget.php?&tw=1&pmid=25908852 #FOAvip Nuclear positioning is a crucial cell function, but how a migrating cell positions its nucleus is not understood. Using traction-force microscopy, we found that the position of the nucleus in migrating fibroblasts closely coincided with the center point of the traction-force balance, called the point of maximum tension (PMT). Positioning of the nucleus close to the PMT required nucleus?cytoskeleton connections through linker of nucleoskeleton-to-cytoskeleton (LINC) complexes. Although the nucleus briefly lagged behind the PMT following spontaneous detachment of the uropod during migration, the nucleus quickly repositioned to the PMT within a few minutes. Moreover, traction-generating spontaneous protrusions deformed the nearby nucleus surface to pull the nuclear centroid toward the new PMT, and subsequent retraction of these protrusions relaxed the nuclear deformation and restored the nucleus to its original position. We propose that the protruding or retracting cell boundary transmits a force to the surface of the nucleus through the intervening cytoskeletal network connected by the LINC complexes, and that these forces help to position the nucleus centrally and allow the nucleus to efficiently propagate traction forces across the length of the cell during migration. Twit Text FOAVip The nucleus is an intracellular propagator of tensile forces in NIH 3T3 fibroblasts ????J Cell Sci http://www.kidney.de/pget.php?&tw=1&pmid=25908852 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25908852 #FOAvip English Wikipedia <ref>{{Cite pmid|25908852}}</ref> The nucleus is an intracellular propagator of tensile forces in NIH 3T3 fibroblasts #MMPMID25908852 Alam SG; Lovett D; Kim DI; Roux KJ; Dickinson RB; Lele TP J Cell Sci 2015[May]; 128 (10): 1901-11 PMID25908852show ga Nuclear positioning is a crucial cell function, but how a migrating cell positions its nucleus is not understood. Using traction-force microscopy, we found that the position of the nucleus in migrating fibroblasts closely coincided with the center point of the traction-force balance, called the point of maximum tension (PMT). Positioning of the nucleus close to the PMT required nucleus?cytoskeleton connections through linker of nucleoskeleton-to-cytoskeleton (LINC) complexes. Although the nucleus briefly lagged behind the PMT following spontaneous detachment of the uropod during migration, the nucleus quickly repositioned to the PMT within a few minutes. Moreover, traction-generating spontaneous protrusions deformed the nearby nucleus surface to pull the nuclear centroid toward the new PMT, and subsequent retraction of these protrusions relaxed the nuclear deformation and restored the nucleus to its original position. We propose that the protruding or retracting cell boundary transmits a force to the surface of the nucleus through the intervening cytoskeletal network connected by the LINC complexes, and that these forces help to position the nucleus centrally and allow the nucleus to efficiently propagate traction forces across the length of the cell during migration. äThe nucleus is an intracellular propagator of tensile forces in NIH 3T(epmc).pdf DeepDyve Pubget Overpricing