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2015 ; 5
(ä): 11085
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Identifying ultrasound and clinical features of breast cancer molecular subtypes
by ensemble decision
#MMPMID26046791
Zhang L
; Li J
; Xiao Y
; Cui H
; Du G
; Wang Y
; Li Z
; Wu T
; Li X
; Tian J
Sci Rep
2015[Jun]; 5
(ä): 11085
PMID26046791
show ga
Breast cancer is molecularly heterogeneous and categorized into four molecular
subtypes: Luminal-A, Luminal-B, HER2-amplified and Triple-negative. In this
study, we aimed to apply an ensemble decision approach to identify the ultrasound
and clinical features related to the molecular subtypes. We collected ultrasound
and clinical features from 1,000 breast cancer patients and performed
immunohistochemistry on these samples. We used the ensemble decision approach to
select unique features and to construct decision models. The decision model for
Luminal-A subtype was constructed based on the presence of an echogenic halo and
post-acoustic shadowing or indifference. The decision model for Luminal-B subtype
was constructed based on the absence of an echogenic halo and vascularity. The
decision model for HER2-amplified subtype was constructed based on the presence
of post-acoustic enhancement, calcification, vascularity and advanced age. The
model for Triple-negative subtype followed two rules. One was based on irregular
shape, lobulate margin contour, the absence of calcification and hypovascularity,
whereas the other was based on oval shape, hypovascularity and micro-lobulate
margin contour. The accuracies of the models were 83.8%, 77.4%, 87.9% and 92.7%,
respectively. We identified specific features of each molecular subtype and
expanded the scope of ultrasound for making diagnoses using these decision
models.