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10.1038/srep11030 http://scihub22266oqcxt.onion/10.1038/srep11030 C4457136!4457136!26046800     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2015 ; 5 (ä): ä Nephropedia Template TP {{tp|p=26046800|t=2015. The Tie2-agonist Vasculotide rescues mice from influenza virus infection |pdf=|usr=}}{{26046800}} gab.com Text The Tie2-agonist Vasculotide rescues mice from influenza virus infection JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26046800 #FOAvip Seasonal influenza virus infections cause hundreds of thousands of deaths annually while viral mutation raises the threat of a novel pandemic strain. Antiviral drugs exhibit limited efficacy unless administered early and may induce viral resistance. Thus, targeting the host response directly has been proposed as a novel therapeutic strategy with the added potential benefit of not eliciting viral resistance. Severe influenza virus infections are complicated by respiratory failure due to the development of lung microvascular leak and acute lung injury. We hypothesized that enhancing lung endothelial barrier integrity could improve the outcome. Here we demonstrate that the Tie2-agonist tetrameric peptide Vasculotide improves survival in murine models of severe influenza, even if administered as late as 72?hours after infection; the benefit was observed using three strains of the virus and two strains of mice. The effect required Tie2, was independent of viral replication and did not impair lung neutrophil recruitment. Administration of the drug decreased lung edema, arterial hypoxemia and lung endothelial apoptosis; importantly, Vasculotide is inexpensive to produce, is chemically stable and is unrelated to any Tie2 ligands. Thus, Vasculotide may represent a novel and practical therapy for severe infections with influenza. Twit Text FOAVip The Tie2-agonist Vasculotide rescues mice from influenza virus infection ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26046800 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26046800 #FOAvip English Wikipedia <ref>{{Cite pmid|26046800}}</ref> The Tie2-agonist Vasculotide rescues mice from influenza virus infection #MMPMID26046800 Sugiyama MG; Armstrong SM; Wang C; Hwang D; Leong-Poi H; Advani A; Advani S; Zhang H; Szaszi K; Tabuchi A; Kuebler WM; Van Slyke P; Dumont DJ; Lee WL Sci Rep 2015[]; 5 (ä): ä PMID26046800show ga Seasonal influenza virus infections cause hundreds of thousands of deaths annually while viral mutation raises the threat of a novel pandemic strain. Antiviral drugs exhibit limited efficacy unless administered early and may induce viral resistance. Thus, targeting the host response directly has been proposed as a novel therapeutic strategy with the added potential benefit of not eliciting viral resistance. Severe influenza virus infections are complicated by respiratory failure due to the development of lung microvascular leak and acute lung injury. We hypothesized that enhancing lung endothelial barrier integrity could improve the outcome. Here we demonstrate that the Tie2-agonist tetrameric peptide Vasculotide improves survival in murine models of severe influenza, even if administered as late as 72?hours after infection; the benefit was observed using three strains of the virus and two strains of mice. The effect required Tie2, was independent of viral replication and did not impair lung neutrophil recruitment. Administration of the drug decreased lung edema, arterial hypoxemia and lung endothelial apoptosis; importantly, Vasculotide is inexpensive to produce, is chemically stable and is unrelated to any Tie2 ligands. Thus, Vasculotide may represent a novel and practical therapy for severe infections with influenza. äThe Tie2-agonist Vasculotide rescues mice from influenza virus infecti(epmc).pdf DeepDyve Pubget Overpricing