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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Front+Endocrinol+(Lausanne)
2015 ; 6
(ä): 91
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Epigenetic Regulation of Non-Lymphoid Cells by Bisphenol A, a Model Endocrine
Disrupter: Potential Implications for Immunoregulation
#MMPMID26097467
Khan D
; Ahmed SA
Front Endocrinol (Lausanne)
2015[]; 6
(ä): 91
PMID26097467
show ga
Endocrine disrupting chemicals (EDC) abound in the environment since many
compounds are released from chemical, agricultural, pharmaceutical, and consumer
product industries. Many of the EDCs such as Bisphenol A (BPA) have estrogenic
activity or interfere with endogenous sex hormones. Experimental studies have
reported a positive correlation of BPA with reproductive toxicity, altered
growth, and immune dysregulation. Although the precise relevance of these studies
to the environmental levels is unclear, nevertheless, their potential health
implications remain a concern. One possible mechanism by which BPA can alter
genes is by regulating epigenetics, including microRNA, alteration of
methylation, and histone acetylation. There is now wealth of information on BPA
effects on non-lymphoid cells and by comparison, paucity of data on effects of
BPA on the immune system. In this mini review, we will highlight the BPA
regulation of estrogen receptor-mediated immune cell functions and in different
inflammatory conditions. In addition, BPA-mediated epigenetic regulation of
non-lymphoid cells is emphasized. We recognize that most of these studies are on
non-lymphoid cells, and given that BPA also affects the immune system, it is
plausible that BPA could have similar epigenetic regulation in immune cells. It
is hoped that this review will stimulate studies in this area to ascertain
whether or not BPA epigenetically regulates the cells of the immune system.