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2015 ; 5
(ä): 10905
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A comparison of NBI and WLI cystoscopy in detecting non-muscle-invasive bladder
cancer: A prospective, randomized and multi-center study
#MMPMID26046790
Ye Z
; Hu J
; Song X
; Li F
; Zhao X
; Chen S
; Wang X
; He D
; Fan J
; Ye D
; Xing J
; Pan T
; Wang D
Sci Rep
2015[Jun]; 5
(ä): 10905
PMID26046790
show ga
Several single-center studies have investigated whether narrow-band imaging (NBI)
cystoscopy is more effective in detecting primary and recurrent non-muscle
invasive bladder cancer (NMIBC) compared with white-light imaging (WLI)
cystoscopy. In this study, we further evaluated the diagnostic value of NBI
cystoscopy compared with WLI cystoscopy for primary NMIBC in a multi-center
study. Suspected bladder cancer patients from 8 research centers received both
NBI and WLI. Two experienced doctors in each center were responsible for the NBI
and WLI assessments, respectively. The number of tumors and position of each
tumor were recorded, and suspicious tissues were clamped and histologically
examined. The sensitivity, specificity, and false-positive rate of NBI and WLI
were evaluated. Of the 384 patients, 78 had a confirmed urothelial carcinoma
(UC). The sensitivities of NBI and WLI were 97.70%, and 66.67%, respectively
(P?0.0001); the specificities were 50% and 25%, respectively; and the false
positive rates were 50% and 75%, respectively. Based on 300 valid biopsy
specimens, the NBI and WLI sensitivities were 98.80% and 75.45%, respectively
(P?0.0001). These results suggest that NBI has a high sensitivity and has
superior early bladder tumor and carcinoma in situ (CIS) detection rates compared
with WLI cystoscopy.