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10.1038/srep09882 http://scihub22266oqcxt.onion/10.1038/srep09882 C4456731!4456731 !26044259     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26044259 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2015 ; 5 (ä): 9882 Nephropedia Template TP {{tp|p=26044259 |t=2015. Efficient in vitro generation of functional thymic epithelial progenitors from human embryonic stem cells |pdf=|usr=}}{{26044259 }} gab.com Text Efficient in vitro generation of functional thymic epithelial progenitors from human embryonic stem cells JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26044259 #FOAvip Thymic epithelial cells (TECs) are the major components of the thymic microenvironment for T cell development. TECs are derived from thymic epithelial progenitors (TEPs). It has been reported that human ESCs (hESCs) can be directed to differentiate into TEPs in vitro. However, the efficiency for the differentiation is low. Furthermore, transplantation of hESC-TEPs in mice only resulted in a very low level of human T cell development from co-transplanted human hematopoietic precursors. We show here that we have developed a novel protocol to efficiently induce the differentiation of hESCs into TEPs in vitro. When transplanted into mice, hESC-TEPs develop into TECs and form a thymic architecture. Most importantly, the hESC-TECs support the long-term development of functional mouse T cells or a higher level of human T cell development from co-transplanted human hematopoietic precursors. The hESC-TEPs may provide a new approach to prevent or treat patients with T cell immunodeficiency. Twit Text FOAVip Efficient in vitro generation of functional thymic epithelial progenitors from human embryonic stem cells ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26044259 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26044259 #FOAvip English Wikipedia <ref>{{Cite pmid|26044259 }}</ref> Efficient in vitro generation of functional thymic epithelial progenitors from human embryonic stem cells #MMPMID26044259 Su M ; Hu R ; Jin J ; Yan Y ; Song Y ; Sullivan R ; Lai L Sci Rep 2015[Jun]; 5 (ä): 9882 PMID26044259 show ga Thymic epithelial cells (TECs) are the major components of the thymic microenvironment for T cell development. TECs are derived from thymic epithelial progenitors (TEPs). It has been reported that human ESCs (hESCs) can be directed to differentiate into TEPs in vitro. However, the efficiency for the differentiation is low. Furthermore, transplantation of hESC-TEPs in mice only resulted in a very low level of human T cell development from co-transplanted human hematopoietic precursors. We show here that we have developed a novel protocol to efficiently induce the differentiation of hESCs into TEPs in vitro. When transplanted into mice, hESC-TEPs develop into TECs and form a thymic architecture. Most importantly, the hESC-TECs support the long-term development of functional mouse T cells or a higher level of human T cell development from co-transplanted human hematopoietic precursors. The hESC-TEPs may provide a new approach to prevent or treat patients with T cell immunodeficiency. |*Cell Differentiation [MESH] |Animals [MESH] |Cell Culture Techniques [MESH] |Epithelial Cells/*cytology/*metabolism [MESH] |Human Embryonic Stem Cells/*cytology/transplantation [MESH] |Humans [MESH] |In Vitro Techniques [MESH] |Lymphopoiesis [MESH] |Mice [MESH] |Mice, Nude [MESH] |Stem Cell Transplantation [MESH] |T-Lymphocytes/cytology/metabolism [MESH]Efficient in vitro generation of functional thymic epithelial progenit(epmc).pdf DeepDyve Pubget Overpricing