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10.1016/j.immuni.2015.02.015 http://scihub22266oqcxt.onion/10.1016/j.immuni.2015.02.015 C4456685!4456685!25786178     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunity 2015 ; 42 (3): 552-65 Nephropedia Template TP {{tp|p=25786178|t=2015. Local triggering of the ICOS coreceptor by CD11c+ myeloid cells drives organ inflammation in lupus |pdf=|usr=}}{{25786178}} gab.com Text Local triggering of the ICOS coreceptor by CD11c+ myeloid cells drives organ inflammation in lupus JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=25786178 #FOAvip The inducible T cell costimulator (ICOS) is a potent promoter of organ inflammation in murine lupus. ICOS stimulates T follicular helper cell differentiation in lymphoid tissue, suggesting that it might drive autoimmunity by enhancing autoantibody production. Yet, the pathogenic relevance of this mechanism remains unclear. It is also unknown whether other ICOS-induced processes might contribute to lupus pathology. Here we show that selective ablation of ICOS ligand (ICOSL) in CD11c+ cells but not in B cells dramatically ameliorates kidney and lung inflammation in lupus-prone MRL. Faslpr mice. Autoantibody formation was largely unaffected by ICOSL deficiency in CD11c+ cells. However, ICOSL display by CD11c+ cells in inflamed organs had a nonredundant role in protecting invading T cells from apoptosis by elevating activity of the PI3K-Akt signaling pathway, thereby facilitating T cell accrual. These findings reveal a mechanism that locally sustains organ inflammation in lupus. Twit Text FOAVip Local triggering of the ICOS coreceptor by CD11c+ myeloid cells drives organ inflammation in lupus ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=25786178 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25786178 #FOAvip English Wikipedia <ref>{{Cite pmid|25786178}}</ref> Local triggering of the ICOS coreceptor by CD11c+ myeloid cells drives organ inflammation in lupus #MMPMID25786178 Teichmann LL; Cullen JL; Kashgarian M; Dong C; Craft J; Shlomchik MJ Immunity 2015[Mar]; 42 (3): 552-65 PMID25786178show ga The inducible T cell costimulator (ICOS) is a potent promoter of organ inflammation in murine lupus. ICOS stimulates T follicular helper cell differentiation in lymphoid tissue, suggesting that it might drive autoimmunity by enhancing autoantibody production. Yet, the pathogenic relevance of this mechanism remains unclear. It is also unknown whether other ICOS-induced processes might contribute to lupus pathology. Here we show that selective ablation of ICOS ligand (ICOSL) in CD11c+ cells but not in B cells dramatically ameliorates kidney and lung inflammation in lupus-prone MRL. Faslpr mice. Autoantibody formation was largely unaffected by ICOSL deficiency in CD11c+ cells. However, ICOSL display by CD11c+ cells in inflamed organs had a nonredundant role in protecting invading T cells from apoptosis by elevating activity of the PI3K-Akt signaling pathway, thereby facilitating T cell accrual. These findings reveal a mechanism that locally sustains organ inflammation in lupus. äLocal triggering of the ICOS coreceptor by CD11c+ myeloid cells drives(epmc).pdf DeepDyve Pubget Overpricing