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2015 ; 5
(ä): 10891
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gab.com Text
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The pericyte as a cellular regulator of penile erection and a novel therapeutic
target for erectile dysfunction
#MMPMID26044953
Yin GN
; Das ND
; Choi MJ
; Song KM
; Kwon MH
; Ock J
; Limanjaya A
; Ghatak K
; Kim WJ
; Hyun JS
; Koh GY
; Ryu JK
; Suh JK
Sci Rep
2015[Jun]; 5
(ä): 10891
PMID26044953
show ga
Pericytes are known to play critical roles in vascular development and
homeostasis. However, the distribution of cavernous pericytes and their roles in
penile erection is unclear. Herein we report that the pericytes are abundantly
distributed in microvessels of the subtunical area and dorsal nerve bundle of
mice, followed by dorsal vein and cavernous sinusoids. We further confirmed the
presence of pericytes in human corpus cavernosum tissue and successfully isolated
pericytes from mouse penis. Cavernous pericyte contents from diabetic mice and
tube formation of cultured pericytes in high glucose condition were greatly
reduced compared with those in normal conditions. Suppression of pericyte
function with anti-PDGFR-? blocking antibody deteriorated erectile function and
tube formation in vivo and in vitro diabetic condition. In contrast, enhanced
pericyte function with HGF protein restored cavernous pericyte content in
diabetic mice, and significantly decreased cavernous permeability in diabetic
mice and in pericytes-endothelial cell co-culture system, which induced
significant recovery of erectile function. Overall, these findings showed the
presence and distribution of pericytes in the penis of normal or pathologic
condition and documented their role in the regulation of cavernous permeability
and penile erection, which ultimately explore novel therapeutics of erectile
dysfunction targeting pericyte function.