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10.1038/cr.2015.60 http://scihub22266oqcxt.onion/10.1038/cr.2015.60 C4456627!4456627 !25998683     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25998683 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Res 2015 ; 25 (6 ): 738-52 Nephropedia Template TP {{tp|p=25998683 |t=2015. Internalization of the TGF-? type I receptor into caveolin-1 and EEA1 double-positive early endosomes |pdf=|usr=}}{{25998683 }} gab.com Text Internalization of the TGF- type I receptor into caveolin-1 and EEA1 double-positive early endosomes JO: Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=25998683 #FOAvip Endocytosis and intracellular sorting of transforming growth factor-? (TGF-?) receptors play an important regulatory role in TGF-? signaling. Two major endocytic pathways, clathrin- and caveolae-mediated endocytosis, have been reported to independently mediate the internalization of TGF-? receptors. In this study, we demonstrate that the clathrin- and caveolae-mediated endocytic pathways can converge during TGF-? receptor endocytic trafficking. By tracking the intracellular dynamics of fluorescently-labeled TGF-? type I receptor (T?RI), we found that after mediating T?RI internalization, certain clathrin-coated vesicles and caveolar vesicles are fused underneath the plasma membrane, forming a novel type of caveolin-1 and clathrin double-positive vesicles. Under the regulation of Rab5, the fused vesicles are targeted to early endosomes and thus deliver the internalized T?RI to the caveolin-1 and EEA1 double-positive early endosomes (caveolin-1-positive early endosomes). We further showed that the caveolin-1-positive early endosomes are positive for Smad3/SARA, Rab11 and Smad7/Smurf2, and may act as a multifunctional device for TGF-? signaling and TGF-? receptor recycling and degradation. Therefore, these findings uncover a novel scenario of endocytosis, the direct fusion of clathrin-coated and caveolae vesicles during TGF-? receptor endocytic trafficking, which leads to the formation of the multifunctional sorting device, caveolin-1-positive early endosomes, for TGF-? receptors. Twit Text FOAVip Internalization of the TGF- type I receptor into caveolin-1 and EEA1 double-positive early endosomes ????Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=25998683 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25998683 #FOAvip English Wikipedia <ref>{{Cite pmid|25998683 }}</ref> Internalization of the TGF-? type I receptor into caveolin-1 and EEA1 double-positive early endosomes #MMPMID25998683 He K ; Yan X ; Li N ; Dang S ; Xu L ; Zhao B ; Li Z ; Lv Z ; Fang X ; Zhang Y ; Chen YG Cell Res 2015[Jun]; 25 (6 ): 738-52 PMID25998683 show ga Endocytosis and intracellular sorting of transforming growth factor-? (TGF-?) receptors play an important regulatory role in TGF-? signaling. Two major endocytic pathways, clathrin- and caveolae-mediated endocytosis, have been reported to independently mediate the internalization of TGF-? receptors. In this study, we demonstrate that the clathrin- and caveolae-mediated endocytic pathways can converge during TGF-? receptor endocytic trafficking. By tracking the intracellular dynamics of fluorescently-labeled TGF-? type I receptor (T?RI), we found that after mediating T?RI internalization, certain clathrin-coated vesicles and caveolar vesicles are fused underneath the plasma membrane, forming a novel type of caveolin-1 and clathrin double-positive vesicles. Under the regulation of Rab5, the fused vesicles are targeted to early endosomes and thus deliver the internalized T?RI to the caveolin-1 and EEA1 double-positive early endosomes (caveolin-1-positive early endosomes). We further showed that the caveolin-1-positive early endosomes are positive for Smad3/SARA, Rab11 and Smad7/Smurf2, and may act as a multifunctional device for TGF-? signaling and TGF-? receptor recycling and degradation. Therefore, these findings uncover a novel scenario of endocytosis, the direct fusion of clathrin-coated and caveolae vesicles during TGF-? receptor endocytic trafficking, which leads to the formation of the multifunctional sorting device, caveolin-1-positive early endosomes, for TGF-? receptors. |Caveolin 1/*metabolism [MESH] |Cells, Cultured [MESH] |Endosomes/*metabolism [MESH] |HeLa Cells [MESH] |Humans [MESH] |Microscopy, Electron [MESH] |Protein Serine-Threonine Kinases/*metabolism [MESH] |Receptor, Transforming Growth Factor-beta Type I [MESH] |Receptors, Transforming Growth Factor beta/*metabolism [MESH]Internalization of the TGF-? type I receptor into caveolin-1 and EEA1 (epmc).pdf DeepDyve Pubget Overpricing