Cushing s disease: towards precision medicine #MMPMID25930709
Kaiser UB
Cell Res 2015[Jun]; 25 (6): 649-50 PMID25930709show ga
The pathogenesis of Cushing's disease is poorly understood; two recent reports identifying somatic mutations in USP8 in pituitary corticotroph tumors provide exciting advances in this field. These mutations alter EGFR trafficking and signaling, raising the prospect that EGFR inhibitors may move the treatment of this disease into the era of precision medicine.