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10.1016/j.cmet.2015.04.010 http://scihub22266oqcxt.onion/10.1016/j.cmet.2015.04.010 C4456254!4456254!25980348     free     free     free       Cell+Metab 2015 ; 21 (6): 855-67 Nephropedia Template TP {{tp|p=25980348|t=2015. snoRNA U17 Regulates Cellular Cholesterol Trafficking |pdf=|usr=}}{{25980348}} gab.com Text snoRNA U17 Regulates Cellular Cholesterol Trafficking JO: Cell Metab http://www.kidney.de/pget.php?&tw=1&pmid=25980348 #FOAvip Cholesterol is required for the growth and viability of mammalian cells, and is an obligate precursor for steroid hormone synthesis. Using a loss-of-function screen for mutants with defects in intracellular cholesterol trafficking, a Chinese hamster ovary cell mutant with haploinsufficiency of the U17 snoRNA was isolated. U17 is a H/ACA orphan snoRNA, for which a function other than ribosomal processing has not previously been identified. Through expression profiling, we identified hypoxia upregulated mitochondrial movement regulator (HUMMR) mRNA as a target that is negatively regulated by U17 snoRNA. Upregulation of HUMMR in U17 snoRNA-deficient cells promoted formation of ER-mitochondrial contacts, decreasing esterification of cholesterol and facilitating cholesterol trafficking to mitochondria. U17 snoRNA and HUMMR regulate mitochondrial synthesis of steroids in vivo, and are developmentally regulated in steroidogenic tissues, suggesting that the U17 snoRNA-HUMMR pathway may serve a previously unrecognized, physiological role in gonadal tissue maturation. Twit Text FOAVip snoRNA U17 Regulates Cellular Cholesterol Trafficking ????Cell Metab http://www.kidney.de/pget.php?&tw=1&pmid=25980348 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25980348 #FOAvip English Wikipedia <ref>{{Cite pmid|25980348}}</ref> snoRNA U17 Regulates Cellular Cholesterol Trafficking #MMPMID25980348 Jinn S; Brandis KA; Ren A; Chacko A; Dudley-Rucker N; Gale S; Sidhu R; Fujiwara H; Jiang H; Olsen BN; Schaffer JE; Ory DS Cell Metab 2015[Jun]; 21 (6): 855-67 PMID25980348show ga Cholesterol is required for the growth and viability of mammalian cells, and is an obligate precursor for steroid hormone synthesis. Using a loss-of-function screen for mutants with defects in intracellular cholesterol trafficking, a Chinese hamster ovary cell mutant with haploinsufficiency of the U17 snoRNA was isolated. U17 is a H/ACA orphan snoRNA, for which a function other than ribosomal processing has not previously been identified. Through expression profiling, we identified hypoxia upregulated mitochondrial movement regulator (HUMMR) mRNA as a target that is negatively regulated by U17 snoRNA. Upregulation of HUMMR in U17 snoRNA-deficient cells promoted formation of ER-mitochondrial contacts, decreasing esterification of cholesterol and facilitating cholesterol trafficking to mitochondria. U17 snoRNA and HUMMR regulate mitochondrial synthesis of steroids in vivo, and are developmentally regulated in steroidogenic tissues, suggesting that the U17 snoRNA-HUMMR pathway may serve a previously unrecognized, physiological role in gonadal tissue maturation. äsnoRNA U17 Regulates Cellular Cholesterol Trafficking (epmc).pdf DeepDyve Pubget Overpricing