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10.1038/nsmb.3018 http://scihub22266oqcxt.onion/10.1038/nsmb.3018 C4456216!4456216!25961797     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Struct+Mol+Biol 2015 ; 22 (6): 476-84 Nephropedia Template TP {{tp|p=25961797|t=2015. Cryptochrome 1 regulates the circadian clock through dynamic interactions with the BMAL1 C-terminus |pdf=|usr=}}{{25961797}} gab.com Text Cryptochrome 1 regulates the circadian clock through dynamic interactions with the BMAL1 C-terminus JO: Nat Struct Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=25961797 #FOAvip The molecular circadian clock in mammals is generated from transcriptional activation by the bHLH-PAS transcription factor CLOCK?BMAL1 and subsequent repression by PERIOD and CRYPTOCHROME (CRY). The mechanism by which CRYs repress CLOCK?BMAL1 to close the negative feedback loop and generate 24-hour timing is not known. Here we show that CRY1 competes for binding with coactivators to the intrinsically unstructured C-terminal transactivation domain (TAD) of BMAL1 to establish a functional switch between activation and repression of CLOCK?BMAL1. Mutations within the TAD that alter affinities for coregulators change the balance of repression and activation to consequently change intrinsic circadian period or eliminate cycling altogether. Our results suggest that CRY1 fulfills its role as an essential circadian repressor by sequestering the TAD from coactivators and highlight regulation of the BMAL1 TAD as a critical mechanism for establishing circadian timing. Twit Text FOAVip Cryptochrome 1 regulates the circadian clock through dynamic interactions with the BMAL1 C-terminus ????Nat Struct Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=25961797 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25961797 #FOAvip English Wikipedia <ref>{{Cite pmid|25961797}}</ref> Cryptochrome 1 regulates the circadian clock through dynamic interactions with the BMAL1 C-terminus #MMPMID25961797 Xu H; Gustafson CL; Sammons PJ; Khan SK; Parsley NC; Ramanathan C; Lee HW; Liu AC; Partch CL Nat Struct Mol Biol 2015[Jun]; 22 (6): 476-84 PMID25961797show ga The molecular circadian clock in mammals is generated from transcriptional activation by the bHLH-PAS transcription factor CLOCK?BMAL1 and subsequent repression by PERIOD and CRYPTOCHROME (CRY). The mechanism by which CRYs repress CLOCK?BMAL1 to close the negative feedback loop and generate 24-hour timing is not known. Here we show that CRY1 competes for binding with coactivators to the intrinsically unstructured C-terminal transactivation domain (TAD) of BMAL1 to establish a functional switch between activation and repression of CLOCK?BMAL1. Mutations within the TAD that alter affinities for coregulators change the balance of repression and activation to consequently change intrinsic circadian period or eliminate cycling altogether. Our results suggest that CRY1 fulfills its role as an essential circadian repressor by sequestering the TAD from coactivators and highlight regulation of the BMAL1 TAD as a critical mechanism for establishing circadian timing. äCryptochrome 1 regulates the circadian clock through dynamic interacti(epmc).pdf DeepDyve Pubget Overpricing