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10.1007/s00441-015-2123-x http://scihub22266oqcxt.onion/10.1007/s00441-015-2123-x C4456210!4456210!25673211     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Tissue+Res 2015 ; 360 (3): 773-83 Nephropedia Template TP {{tp|p=25673211|t=2015. New Functions for Alpha-Catenins in Health and Disease: From Cancer to Heart Regeneration |pdf=|usr=}}{{25673211}} gab.com Text New Functions for Alpha-Catenins in Health and Disease: From Cancer to Heart Regeneration JO: Cell Tissue Res http://www.kidney.de/pget.php?&tw=1&pmid=25673211 #FOAvip Strong cell-cell adhesion mediated by adherens junctions is dependent on anchoring the transmembrane cadherin molecule to the underlying actin cytoskeleton. To do this, cadherin cytoplasmic domain interacts with catenin proteins, which include ?-catenin that binds directly to filamentous actin. Originally thought to be a static structure, the connection between the cadherin/catenin adhesion complex and the actin cytoskeleton is now considered to be dynamic and responsive to both intercellular and intracellular signals. Alpha-catenins are mechanosensing proteins that undergo conformational change in response to cytoskeletal tension thus modifying the linkage between the cadherin and the actin cytoskeleton. There are three ?-catenin isoforms expressed in mouse and human: ?E-catenin (CTNNA1), ?N-catenin (CTNNA2), and ?T-catenin (CTNNA3). This review summarizes recent progress in understanding the in vivo function(s) of ?-catenins in tissue morphogenesis, homeostasis, and disease. The role of ?-catenin in the regulation of cellular proliferation will be discussed in the context of cancer and regeneration. Twit Text FOAVip New Functions for Alpha-Catenins in Health and Disease: From Cancer to Heart Regeneration ????Cell Tissue Res http://www.kidney.de/pget.php?&tw=1&pmid=25673211 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25673211 #FOAvip English Wikipedia <ref>{{Cite pmid|25673211}}</ref> New Functions for Alpha-Catenins in Health and Disease: From Cancer to Heart Regeneration #MMPMID25673211 Vite A; Li J; Radice GL Cell Tissue Res 2015[Jun]; 360 (3): 773-83 PMID25673211show ga Strong cell-cell adhesion mediated by adherens junctions is dependent on anchoring the transmembrane cadherin molecule to the underlying actin cytoskeleton. To do this, cadherin cytoplasmic domain interacts with catenin proteins, which include ?-catenin that binds directly to filamentous actin. Originally thought to be a static structure, the connection between the cadherin/catenin adhesion complex and the actin cytoskeleton is now considered to be dynamic and responsive to both intercellular and intracellular signals. Alpha-catenins are mechanosensing proteins that undergo conformational change in response to cytoskeletal tension thus modifying the linkage between the cadherin and the actin cytoskeleton. There are three ?-catenin isoforms expressed in mouse and human: ?E-catenin (CTNNA1), ?N-catenin (CTNNA2), and ?T-catenin (CTNNA3). This review summarizes recent progress in understanding the in vivo function(s) of ?-catenins in tissue morphogenesis, homeostasis, and disease. The role of ?-catenin in the regulation of cellular proliferation will be discussed in the context of cancer and regeneration. äNew Functions for Alpha-Catenins in Health and Disease: From Cancer to(epmc).pdf DeepDyve Pubget Overpricing