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10.1111/bcp.12577 http://scihub22266oqcxt.onion/10.1111/bcp.12577 C4456133!4456133 !25556909     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25556909 &cmd=llinks): Failed to open stream: HTTP request failed! 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Indications of newer and older anti-epileptic drug use: findings from a southern Italian general practice setting from 2005-2011 |pdf=|usr=}}{{25556909 }} gab.com Text Indications of newer and older anti-epileptic drug use: findings from a southern Italian general practice setting from 2005-2011 JO: Br J Clin Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=25556909 #FOAvip AIMS: The aim of the study was to analyze the prescribing pattern of both newer and older AEDs. METHODS: A population of almost 150 000 individuals registered with 123 general practitioners was included in this study. Patients who received at least one AED prescription over 2005-2011 were identified. The 1 year prevalence and cumulative incidence of AED use, by drug class and individual drug, were calculated over the study period. Potential predictors of starting therapy with newer AEDs were also investigated. RESULTS: The prevalence of use per 1000 inhabitants of older AEDs increased from 10.7 (95% CI10.1, 11.2) in 2005 to 13.0 (95% CI12.4, 13.6) in 2011, while the incidence remained stable. Newer AED incidence decreased from 9.4 (95% CI 8.9, 9.9) in 2005 to 7.0 (95% CI 6.6, 7.5) in 2011, with a peak of 15.5 (95% CI 14.8, 16.1) in 2006. Phenobarbital and valproic acid were the most commonly prescribed AEDs as starting therapy for epilepsy. Gabapentin and pregabalin accounted for most new pain-related prescriptions, while valproic acid and lamotrigine were increasingly used for mood disorders. Female gender (OR 1.36, 95% CI 1.20, 1.53), age ranging between 45-54 years (OR 1.39, 95% CI 1.16, 1.66) and pain as an indication (OR 16.7, 95% CI, 13.1, 21.2) were associated with newer AEDs starting therapy. CONCLUSIONS: Older AEDs were mainly used for epileptic and mood disorders, while newer drugs were preferred for neuropathic pain. Gender, age, indication of use and year of starting therapy influenced the choice of AED type. The decrease of newer AED use during 2007 is probably related to the restricted reimbursement criteria for gabapentin and pregabalin. Twit Text FOAVip Indications of newer and older anti-epileptic drug use: findings from a southern Italian general practice setting from 2005-2011 ????Br J Clin Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=25556909 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25556909 #FOAvip English Wikipedia <ref>{{Cite pmid|25556909 }}</ref> Indications of newer and older anti-epileptic drug use: findings from a southern Italian general practice setting from 2005-2011 #MMPMID25556909 Italiano D ; Capuano A ; Alibrandi A ; Ferrara R ; Cannata A ; Trifirņ G ; Sultana J ; Ferrajolo C ; Tari M ; Tari DU ; Perrotta M ; Pagliaro C ; Rafaniello C ; Spina E ; Arcoraci V Br J Clin Pharmacol 2015[Jun]; 79 (6 ): 1010-9 PMID25556909 show ga AIMS: The aim of the study was to analyze the prescribing pattern of both newer and older AEDs. METHODS: A population of almost 150 000 individuals registered with 123 general practitioners was included in this study. Patients who received at least one AED prescription over 2005-2011 were identified. The 1 year prevalence and cumulative incidence of AED use, by drug class and individual drug, were calculated over the study period. Potential predictors of starting therapy with newer AEDs were also investigated. RESULTS: The prevalence of use per 1000 inhabitants of older AEDs increased from 10.7 (95% CI10.1, 11.2) in 2005 to 13.0 (95% CI12.4, 13.6) in 2011, while the incidence remained stable. Newer AED incidence decreased from 9.4 (95% CI 8.9, 9.9) in 2005 to 7.0 (95% CI 6.6, 7.5) in 2011, with a peak of 15.5 (95% CI 14.8, 16.1) in 2006. Phenobarbital and valproic acid were the most commonly prescribed AEDs as starting therapy for epilepsy. Gabapentin and pregabalin accounted for most new pain-related prescriptions, while valproic acid and lamotrigine were increasingly used for mood disorders. Female gender (OR 1.36, 95% CI 1.20, 1.53), age ranging between 45-54 years (OR 1.39, 95% CI 1.16, 1.66) and pain as an indication (OR 16.7, 95% CI, 13.1, 21.2) were associated with newer AEDs starting therapy. CONCLUSIONS: Older AEDs were mainly used for epileptic and mood disorders, while newer drugs were preferred for neuropathic pain. Gender, age, indication of use and year of starting therapy influenced the choice of AED type. The decrease of newer AED use during 2007 is probably related to the restricted reimbursement criteria for gabapentin and pregabalin. |Adolescent [MESH] |Adult [MESH] |Age Factors [MESH] |Aged [MESH] |Analgesics/therapeutic use [MESH] |Anticonvulsants/economics/*therapeutic use [MESH] |Antipsychotic Agents/therapeutic use [MESH] |Databases, Factual [MESH] |Drug Costs [MESH] |Drug Prescriptions [MESH] |Drug Utilization Review [MESH] |Epilepsy/diagnosis/*drug therapy/economics/epidemiology [MESH] |Female [MESH] |General Practice/economics/*trends [MESH] |General Practitioners/economics/*trends [MESH] |Health Care Surveys [MESH] |Humans [MESH] |Incidence [MESH] |Insurance, Health, Reimbursement [MESH] |Italy/epidemiology [MESH] |Male [MESH] |Middle Aged [MESH] |Mood Disorders/drug therapy/epidemiology [MESH] |Pain/drug therapy/epidemiology [MESH] |Practice Patterns, Physicians'/economics/*trends [MESH] |Prevalence [MESH] |Sex Factors [MESH] |Time Factors [MESH]Indications of newer and older anti-epileptic drug use: findings from (epmc).pdf DeepDyve Pubget Overpricing