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10.1016/j.mvr.2009.10.005 http://scihub22266oqcxt.onion/10.1016/j.mvr.2009.10.005 C4455889!4455889 !19850054     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\19850054 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Microvasc+Res 2010 ; 79 (1 ): 1-9 Nephropedia Template TP {{tp|p=19850054 |t=2010. Semaphorin 5A promotes angiogenesis by increasing endothelial cell proliferation, migration, and decreasing apoptosis |pdf=|usr=}}{{19850054 }} gab.com Text Semaphorin 5A promotes angiogenesis by increasing endothelial cell proliferation, migration, and decreasing apoptosis JO: Microvasc Res http://www.kidney.de/pget.php?&tw=1&pmid=19850054 #FOAvip Semaphorin 5A (mouse, Sema5A; human, SEMA5A), is an axon regulator molecule and plays major roles during neuronal and vascular development. The importance of Sema5A during vasculogenesis, however, is unclear. The fact that Sema5A deficient mice display a defective branching of cranial vasculature supports its participation in blood vessel formation. In this study, we tested our hypothesis that Sema5A regulates angiogenesis by modulating various steps during angiogenesis. Accordingly, we demonstrated that the treatment of immortalized endothelial cells with recombinant extracellular domain of mouse Sema5A significantly increased endothelial cell proliferation and migration and decreased apoptosis. We also observed a relative increase of endothelial expression of anti-apoptotic genes relative to pro-apoptotic genes in Sema5A-treated endothelial cells suggesting its role in inhibition of apoptosis. In addition, our data suggest that Sema5A decreases apoptosis through activation of Akt, increases migration through activating Met tyrosine kinases and extracellular matrix degradation through matrix metalloproteinase 9. Moreover, in vivo Matrigel plug assays demonstrated that Sema5A induces endothelial cell migration from pre-existing vessels. In conclusion, the present work shows the pro-angiogenic role of Sema5A and provides clues on the signaling pathways that underlie them. Twit Text FOAVip Semaphorin 5A promotes angiogenesis by increasing endothelial cell proliferation, migration, and decreasing apoptosis ????Microvasc Res http://www.kidney.de/pget.php?&tw=1&pmid=19850054 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19850054 #FOAvip English Wikipedia <ref>{{Cite pmid|19850054 }}</ref> Semaphorin 5A promotes angiogenesis by increasing endothelial cell proliferation, migration, and decreasing apoptosis #MMPMID19850054 Sadanandam A ; Rosenbaugh EG ; Singh S ; Varney M ; Singh RK Microvasc Res 2010[Jan]; 79 (1 ): 1-9 PMID19850054 show ga Semaphorin 5A (mouse, Sema5A; human, SEMA5A), is an axon regulator molecule and plays major roles during neuronal and vascular development. The importance of Sema5A during vasculogenesis, however, is unclear. The fact that Sema5A deficient mice display a defective branching of cranial vasculature supports its participation in blood vessel formation. In this study, we tested our hypothesis that Sema5A regulates angiogenesis by modulating various steps during angiogenesis. Accordingly, we demonstrated that the treatment of immortalized endothelial cells with recombinant extracellular domain of mouse Sema5A significantly increased endothelial cell proliferation and migration and decreased apoptosis. We also observed a relative increase of endothelial expression of anti-apoptotic genes relative to pro-apoptotic genes in Sema5A-treated endothelial cells suggesting its role in inhibition of apoptosis. In addition, our data suggest that Sema5A decreases apoptosis through activation of Akt, increases migration through activating Met tyrosine kinases and extracellular matrix degradation through matrix metalloproteinase 9. Moreover, in vivo Matrigel plug assays demonstrated that Sema5A induces endothelial cell migration from pre-existing vessels. In conclusion, the present work shows the pro-angiogenic role of Sema5A and provides clues on the signaling pathways that underlie them. |*Apoptosis/genetics [MESH] |*Cell Movement [MESH] |*Cell Proliferation [MESH] |*Neovascularization, Physiologic [MESH] |Actin Cytoskeleton/metabolism [MESH] |Animals [MESH] |Cell Line [MESH] |Endothelial Cells/*metabolism/pathology [MESH] |Gene Expression Regulation [MESH] |Humans [MESH] |Matrix Metalloproteinase 9/metabolism [MESH] |Membrane Proteins/*metabolism [MESH] |Mice [MESH] |Nerve Tissue Proteins/genetics/*metabolism [MESH] |Neural Cell Adhesion Molecules/genetics/metabolism [MESH] |Phosphorylation [MESH] |Proto-Oncogene Proteins c-akt/metabolism [MESH] |Proto-Oncogene Proteins c-met/metabolism [MESH] |RNA Interference [MESH] |Receptors, Growth Factor/metabolism [MESH] |Recombinant Proteins/metabolism [MESH] |Semaphorins [MESH] |Signal Transduction [MESH] |Time Factors [MESH]Semaphorin 5A promotes angiogenesis by increasing endothelial cell pro(epmc).pdf DeepDyve Pubget Overpricing