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Alteration of Type I collagen microstructure induced by estrogen depletion can be
prevented with drug treatment
#MMPMID26131356
Cauble MA
; Rothman E
; Welch K
; Fang M
; Duong LT
; Pennypacker BL
; Orr BG
; Banaszak Holl MM
Bonekey Rep
2015[]; 4
(?): 697
PMID26131356
show ga
Two independent biological replicates of estrogen depletion were employed with
differing drug treatment conditions. Data Set I consisted of 9-month-old New
Zealand white female rabbits treated as follows: sham-operated (n=11),
ovariectomized (OVX; n=12), OVX+200??g?kg(-1) alendronate (ALN), 3 × a week for
27 weeks (n=12) and OVX+10?mg?kg(-1) Cathepsin-K inhibitor (CatKI) daily for 27
weeks. Data Set II consisted of 6-month-old New Zealand white female rabbits that
were sham-operated (n=12), OVX (n=12) or OVX+0.05?mg?kg(-1) 17?-estradiol (ERT) 3
× a week for 13 weeks (n=12). Samples from the cortical femur were polished and
demineralized to make them suitable for atomic force microscopy (AFM) imaging.
Type I collagen fibrils present in bundles or sheets, running parallel to each
other, were combined into a class termed Parallel. Fibrils present outside of
such structures, typically in images with an angular range of non-parallel
fibrils, were combined into a class termed Oblique. The percentage of fibrils
coded as Parallel for Sham animals in Data Sets I and II was 52% and 53%,
respectively. The percentage of fibrils coded as Parallel for OVX animals in Data
Sets I and II was 35% in both cases. ALN and ERT drug treatments reduced the
change from 18 to 12%, whereas CatKI treatment reduced the change to 5%.
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