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10.1038/srep10979 http://scihub22266oqcxt.onion/10.1038/srep10979 C4455286!4455286!26042604     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2015 ; 5 (ä): ä Nephropedia Template TP {{tp|p=26042604|t=2015. Pathway-based gene signatures predicting clinical outcome of lung adenocarcinoma |pdf=|usr=}}{{26042604}} gab.com Text Pathway-based gene signatures predicting clinical outcome of lung adenocarcinoma JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26042604 #FOAvip Lung adenocarcinoma is often diagnosed at an advanced stage with poor prognosis. Patients with different clinical outcomes may have similar clinico-pathological characteristics. The results of previous studies for biomarkers for lung adenocarcinoma have generally been inconsistent and limited in clinical application. In this study, we used inverse-variance weighting to combine the hazard ratios for the four datasets and performed pathway analysis to identify prognosis-associated gene signatures. A total of 2,418 genes were found to be significantly associated with overall survival. Of these, a 21-gene signature in the HMGB1/RAGE signalling pathway and a 31-gene signature in the clathrin-coated vesicle cycle pathway were significantly associated with prognosis of lung adenocarcinoma across all four datasets (all p-values?<?0.05, log-rank test). We combined the scores for the three pathways to derive a combined pathway-based risk (CPBR) score. Three pathway-based signatures and CPBR score also had more predictive power than single genes. Finally, the CPBR score was validated in two independent cohorts (GSE14814 and GSE13213 in the GEO database) and had significant adjusted hazard ratios 2.72 (p-value?<?0.0001) and 1.71 (p-value?<?0.0001), respectively. These results could provide a more complete picture of the lung cancer pathogenesis. Twit Text FOAVip Pathway-based gene signatures predicting clinical outcome of lung adenocarcinoma ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26042604 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26042604 #FOAvip English Wikipedia <ref>{{Cite pmid|26042604}}</ref> Pathway-based gene signatures predicting clinical outcome of lung adenocarcinoma #MMPMID26042604 Chang YH; Chen CM; Chen HY; Yang PC Sci Rep 2015[]; 5 (ä): ä PMID26042604show ga Lung adenocarcinoma is often diagnosed at an advanced stage with poor prognosis. Patients with different clinical outcomes may have similar clinico-pathological characteristics. The results of previous studies for biomarkers for lung adenocarcinoma have generally been inconsistent and limited in clinical application. In this study, we used inverse-variance weighting to combine the hazard ratios for the four datasets and performed pathway analysis to identify prognosis-associated gene signatures. A total of 2,418 genes were found to be significantly associated with overall survival. Of these, a 21-gene signature in the HMGB1/RAGE signalling pathway and a 31-gene signature in the clathrin-coated vesicle cycle pathway were significantly associated with prognosis of lung adenocarcinoma across all four datasets (all p-values? äPathway-based gene signatures predicting clinical outcome of lung aden(epmc).pdf DeepDyve Pubget Overpricing