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10.1038/srep10937 http://scihub22266oqcxt.onion/10.1038/srep10937 C4455245!4455245 !26042523     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26042523 &cmd=llinks): Failed to open stream: HTTP request failed! 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TonEBP suppresses adipogenesis and insulin sensitivity by blocking epigenetic transition of PPAR?2 |pdf=|usr=}}{{26042523 }} gab.com Text TonEBP suppresses adipogenesis and insulin sensitivity by blocking epigenetic transition of PPAR 2 JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26042523 #FOAvip TonEBP is a key transcription factor in cellular adaptation to hypertonic stress, and also in macrophage activation. Since TonEBP is involved in inflammatory diseases such as rheumatoid arthritis and atherosclerosis, we asked whether TonEBP played a role in adipogenesis and insulin resistance. Here we report that TonEBP suppresses adipogenesis and insulin signaling by inhibiting expression of the key transcription factor PPAR?2. TonEBP binds to the PPAR?2 promoter and blocks the epigenetic transition of the locus which is required for the activation of the promoter. When TonEBP expression is reduced, the epigenetic transition and PPAR?2 expression are markedly increased leading to enhanced adipogenesis and insulin response while inflammation is reduced. Thus, TonEBP is an independent determinant of adipose insulin sensitivity and inflammation. TonEBP is an attractive therapeutic target for insulin resistance in lieu of PPAR? agonists. Twit Text FOAVip TonEBP suppresses adipogenesis and insulin sensitivity by blocking epigenetic transition of PPAR 2 ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26042523 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26042523 #FOAvip English Wikipedia <ref>{{Cite pmid|26042523 }}</ref> TonEBP suppresses adipogenesis and insulin sensitivity by blocking epigenetic transition of PPAR?2 #MMPMID26042523 Lee JH ; Lee HH ; Ye BJ ; Lee-Kwon W ; Choi SY ; Kwon HM Sci Rep 2015[Jun]; 5 (ä): 10937 PMID26042523 show ga TonEBP is a key transcription factor in cellular adaptation to hypertonic stress, and also in macrophage activation. Since TonEBP is involved in inflammatory diseases such as rheumatoid arthritis and atherosclerosis, we asked whether TonEBP played a role in adipogenesis and insulin resistance. Here we report that TonEBP suppresses adipogenesis and insulin signaling by inhibiting expression of the key transcription factor PPAR?2. TonEBP binds to the PPAR?2 promoter and blocks the epigenetic transition of the locus which is required for the activation of the promoter. When TonEBP expression is reduced, the epigenetic transition and PPAR?2 expression are markedly increased leading to enhanced adipogenesis and insulin response while inflammation is reduced. Thus, TonEBP is an independent determinant of adipose insulin sensitivity and inflammation. TonEBP is an attractive therapeutic target for insulin resistance in lieu of PPAR? agonists. |*Epigenesis, Genetic [MESH] |3T3-L1 Cells [MESH] |Adipocytes/cytology/metabolism [MESH] |Adipogenesis/*genetics [MESH] |Adiponectin/genetics/metabolism [MESH] |Animals [MESH] |Cell Differentiation/genetics [MESH] |Chromatin/metabolism [MESH] |Cytokines/genetics/metabolism [MESH] |Down-Regulation [MESH] |Gene Expression Regulation [MESH] |Gene Knockdown Techniques [MESH] |Histones/metabolism [MESH] |Inflammation Mediators/metabolism [MESH] |Insulin Resistance/*genetics [MESH] |Methylation [MESH] |Mice [MESH] |NFATC Transcription Factors/genetics/*metabolism [MESH] |PPAR gamma/*genetics [MESH] |Promoter Regions, Genetic [MESH] |Protein Binding [MESH] |Signal Transduction [MESH]TonEBP suppresses adipogenesis and insulin sensitivity by blocking epi(epmc).pdf DeepDyve Pubget Overpricing