Mitochondrial Ion Channels in Cancer Transformation #MMPMID26090338
Madamba SM; Damri KN; Dejean LM; Peixoto PM
Front Oncol 2015[]; 5 (ä): ä PMID26090338show ga
Cancer transformation involves reprograming of mitochondrial function to avert cell death mechanisms, monopolize energy metabolism, accelerate mitotic proliferation, and promote metastasis. Mitochondrial ion channels have emerged as promising therapeutic targets because of their connection to metabolic and apoptotic functions. This mini review discusses how mitochondrial channels may be associated with cancer transformation and expands on the possible involvement of mitochondrial protein import complexes in pathophysiological process.